Polák, P., Garland, W., Rathore, O., Schmid, M., Salerno-Kochan, A., Jakobsen, L., et al. (2023). Dual agonistic and antagonistic roles of ZC3H18 provide for co-activation of distinct nuclear RNA decay pathways. Cell Reports, 42(11): 113325. doi:10.1016/j.celrep.2023.113325.