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  kcnj13 regulates pigment cell shapes in zebrafish and has diverged by cis-regulatory evolution between Danio species

Podobnik, M., Singh, A. P., Fu, Z., Dooley, C. M., Frohnhofer, H. G., Firlej, M., et al. (2023). kcnj13 regulates pigment cell shapes in zebrafish and has diverged by cis-regulatory evolution between Danio species. DEVELOPMENT, 150(16): dev201627. doi:10.1242/dev.201627.

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 Creators:
Podobnik, Marco, Author
Singh, Ajeet P., Author
Fu, Zhenqiang, Author
Dooley, Christopher M.1, 2, Author           
Frohnhofer, Hans Georg, Author
Firlej, Magdalena, Author
Stednitz, Sarah J., Author
Elhabashy, Hadeer, Author
Weyand, Simone, Author
Weir, John R., Author
Lu, Jianguo, Author
Nuesslein-Volhard, Christiane, Author
Irion, Uwe, Author
Affiliations:
1Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3375716              
2Developmental Genetics, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591697              

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 Abstract: Teleost fish of the genus Danio are excellent models to study the genetic and cellular bases of pigment pattern variation in vertebrates. The two sister species Danio rerio and Danio aesculapii show divergent patterns of horizontal stripes and vertical bars that are partly caused by the divergence of the potassium channel gene kcnj13. Here, we show that kcnj13 is required only in melanophores for interactions with xanthophores and iridophores, which cause location-specific pigment cell shapes and thereby influence colour pattern and contrast in D. rerio. Cis-regulatory rather than protein coding changes underlie kcnj13 divergence between the two Danio species. Our results suggest that homotypic and heterotypic interactions between the pigment cells and their shapes diverged between species by quantitative changes in kcnj13 expression during pigment pattern diversification.

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 Dates: 2023-08-242023-08-15
 Publication Status: Issued
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 Rev. Type: -
 Identifiers: ISI: 001072139600002
DOI: 10.1242/dev.201627
PMID: 37530080
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Title: DEVELOPMENT
Source Genre: Journal
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Pages: - Volume / Issue: 150 (16) Sequence Number: dev201627 Start / End Page: - Identifier: ISSN: 0950-1991