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  The regional variation of laminar thickness in the human isocortex is related to cortical hierarchy and interregional connectivity

Saberi, A., Paquola, C., Wagstyl, K., Hettwer, M., Bernhardt, B. C., Eickhoff, S. B., et al. (2023). The regional variation of laminar thickness in the human isocortex is related to cortical hierarchy and interregional connectivity. PLoS Biology, 21(11): e3002365. doi:10.1371/journal.pbio.3002365.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000D-EA0B-0 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000F-44AE-1
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https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002365#sec034 (Ergänzendes Material)
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 Urheber:
Saberi, Amin1, 2, 3, Autor                 
Paquola, Casey2, Autor
Wagstyl, Konrad4, Autor
Hettwer, Meike1, 2, 3, 5, Autor           
Bernhardt, Boris C.6, Autor
Eickhoff, Simon B.2, 3, Autor
Valk, Sofie L.1, 2, 3, Autor                 
Affiliations:
1Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              
2Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
3Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany, ou_persistent22              
4Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
5Max Planck School of Cognition, Max Planck Schools, Max Planck Society, ou_3473635              
6Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, QC, Canada, ou_persistent22              

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 Zusammenfassung: The human isocortex consists of tangentially organized layers with unique cytoarchitectural properties. These layers show spatial variations in thickness and cytoarchitecture across the neocortex, which is thought to support function through enabling targeted corticocortical connections. Here, leveraging maps of the 6 cortical layers based on 3D human brain histology, we aimed to quantitatively characterize the systematic covariation of laminar structure in the cortex and its functional consequences. After correcting for the effect of cortical curvature, we identified a spatial pattern of changes in laminar thickness covariance from lateral frontal to posterior occipital regions, which differentiated the dominance of infra- versus supragranular layer thickness. Corresponding to the laminar regularities of cortical connections along cortical hierarchy, the infragranular-dominant pattern of laminar thickness was associated with higher hierarchical positions of regions, mapped based on resting-state effective connectivity in humans and tract-tracing of structural connections in macaques. Moreover, we show that regions with similar laminar thickness patterns have a higher likelihood of structural connections and strength of functional connections. In sum, here, we characterize the organization of laminar thickness in the human isocortex and its association with cortico-cortical connectivity, illustrating how laminar organization may provide a foundational principle of cortical function.

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Sprache(n): eng - English
 Datum: 2023-03-282023-10-062023-11-092023-11-09
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1371/journal.pbio.3002365
Anderer: eCollection 2023
PMID: 37943873
 Art des Abschluß: -

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Projektinformation

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Projektname : -
Grant ID : InterLabs-0015
Förderprogramm : -
Förderorganisation : Helmholtz Association
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Canada First Research Excellence Fund (CFREF)
Projektname : Otto Hahn award
Grant ID : -
Förderprogramm : -
Förderorganisation : Max Planck Society
Projektname : -
Grant ID : 215901/Z/19/Z
Förderprogramm : -
Förderorganisation : Wellcome Trust
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : German Federal Ministry of Education and Research (BMBF)
Projektname : -
Grant ID : NI17-039
Förderprogramm : -
Förderorganisation : SickKids Foundation
Projektname : -
Grant ID : Discovery-1304413
Förderprogramm : -
Förderorganisation : National Sciences and Engineering Research Council of Canada (NSERC)
Projektname : -
Grant ID : FDN-154298
Förderprogramm : -
Förderorganisation : Canadian Institutes of Health Research (CIHR)
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Azrieli Center for Autism Research (ACAR)

Quelle 1

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Titel: PLoS Biology
  Andere : PLoS Biol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: San Francisco, California, US : Public Library of Science
Seiten: - Band / Heft: 21 (11) Artikelnummer: e3002365 Start- / Endseite: - Identifikator: ISSN: 1544-9173
CoNE: https://pure.mpg.de/cone/journals/resource/111056649444170