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  The neuroanatomical substrates of autism and ADHD and their link to putative genomic underpinnings

Berg, L. M., Gurr, C., Leyhausen, J., Seelemeyer, H., Bletsch, A., Schaefer, T., Pretzsch, C. M., Oakley, B., Loth, E., Floris, D. L., Buitelaar, J. K., Beckmann, C. F., Banaschewski, T., Charman, T., Jones, E. J. H., Tillmann, J., Chatham, C. H., Bourgeron, T., Ahmad, J., Ambrosino, S., Auyeung, B., Baron-Cohen, S., Baumeister, S., Bölte, S., Bours, C., Brammer, M., Brandeis, D., Brogna, C., de Bruijn, Y., Chakrabarti, B., Cornelissen, I., Crawley, D., Dell’Acqua, F., Dumas, G., Durston, S., Faulkner, J., Frouin, V., Garcés, P., Goyard, D., Ham, L., Hayward, H., Hipp, J., Holt, R., Johnson, M. H., Kundu, P., Lai, M.-C., D’Ardhuy, X. L., Lombardo, M. V., Lythgoe, D. J., Mandl, R., Marquand, A., Mason, L., Mennes, M., Meyer-Lindenberg, A., Moessnang, C., Bast, N., O’Dwyer, L., Oldehinkel, M., Oranje, B., Pandina, G., Persico, A. M., Ruggeri, B., Ruigrok, A., Sabet, J., Sacco, R., Cáceres, A. S. J., Simonoff, E., Spooren, W., Toro, R., Tost, H., Waldman, J., Williams, S. C. R., Wooldridge, C., Zwiers, M. P., Murphy, D. G., & Ecker, C. (2023). The neuroanatomical substrates of autism and ADHD and their link to putative genomic underpinnings. Molecular Autism, 14:. doi:10.1186/s13229-023-00568-z.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-000D-ECBB-7 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000D-ECBC-6
資料種別: 学術論文

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Berg_2023_TheNeuroanatomical.pdf (出版社版), 2MB
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ファイルのパーマリンク:
https://hdl.handle.net/21.11116/0000-000D-ECBD-5
ファイル名:
Berg_2023_TheNeuroanatomical.pdf
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Gold
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公開
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application/pdf / [MD5]
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著作権日付:
2023
著作権情報:
© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons. org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
CCライセンス:
http://creativecommons.org/licenses/by/4.0/

作成者

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 作成者:
Berg, Lisa M., 著者
Gurr, Caroline, 著者
Leyhausen, Johanna, 著者
Seelemeyer, Hanna, 著者
Bletsch, Anke, 著者
Schaefer, Tim1, 2, 著者
Pretzsch, Charlotte M., 著者
Oakley, Bethany, 著者
Loth, Eva, 著者
Floris, Dorothea L., 著者
Buitelaar, Jan K., 著者
Beckmann, Christian F., 著者
Banaschewski, Tobias, 著者
Charman, Tony, 著者
Jones, Emily J. H., 著者
Tillmann, Julian, 著者
Chatham, Chris H., 著者
Bourgeron, Thomas, 著者
Ahmad, Jumana, 著者
Ambrosino, Sara, 著者
Auyeung, Bonnie, 著者Baron-Cohen, Simon, 著者Baumeister, Sarah, 著者Bölte, Sven, 著者Bours, Carsten, 著者Brammer, Michael, 著者Brandeis, Daniel, 著者Brogna, Claudia, 著者de Bruijn, Yvette, 著者Chakrabarti, Bhismadev, 著者Cornelissen, Ineke, 著者Crawley, Daisy, 著者Dell’Acqua, Flavio, 著者Dumas, Guillaume, 著者Durston, Sarah, 著者Faulkner, Jessica, 著者Frouin, Vincent, 著者Garcés, Pilar, 著者Goyard, David, 著者Ham, Lindsay, 著者Hayward, Hannah, 著者Hipp, Joerg, 著者Holt, Rosemary, 著者Johnson, Mark H., 著者Kundu, Prantik, 著者Lai, Meng-Chuan, 著者D’Ardhuy, Xavier Liogier, 著者Lombardo, Michael V., 著者Lythgoe, David J., 著者Mandl, René, 著者Marquand, Andre, 著者Mason, Luke, 著者Mennes, Maarten, 著者Meyer-Lindenberg, Andreas, 著者Moessnang, Carolin, 著者Bast, Nico, 著者O’Dwyer, Laurence, 著者Oldehinkel, Marianne, 著者Oranje, Bob, 著者Pandina, Gahan, 著者Persico, Antonio M., 著者Ruggeri, Barbara, 著者Ruigrok, Amber, 著者Sabet, Jessica, 著者Sacco, Roberto, 著者Cáceres, Antonia San José, 著者Simonoff, Emily, 著者Spooren, Will, 著者Toro, Roberto, 著者Tost, Heike, 著者Waldman, Jack, 著者Williams, Steve C. R., 著者Wooldridge, Caroline, 著者Zwiers, Marcel P., 著者Murphy, Declan G., 著者Ecker, Christine, 著者 全て表示
所属:
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstr. 46, 60528 Frankfurt, DE, ou_2074314              
2Fries Lab, Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstraße 46, 60528 Frankfurt, DE, ou_3381216              

内容説明

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キーワード: ASD, ADHD, Neurodevelopmental disorders, Comorbidity, Imaging-genetics, Structural MRI
 要旨: Background
Autism spectrum disorders (ASD) are neurodevelopmental conditions accompanied by differences in brain development. Neuroanatomical differences in autism are variable across individuals and likely underpin distinct clinical phenotypes. To parse heterogeneity, it is essential to establish how the neurobiology of ASD is modulated by differences associated with co-occurring conditions, such as attention-deficit/hyperactivity disorder (ADHD). This study aimed to (1) investigate between-group differences in autistic individuals with and without co-occurring ADHD, and to (2) link these variances to putative genomic underpinnings.

Methods
We examined differences in cortical thickness (CT) and surface area (SA) and their genomic associations in a sample of 533 individuals from the Longitudinal European Autism Project. Using a general linear model including main effects of autism and ADHD, and an ASD-by-ADHD interaction, we examined to which degree ADHD modulates the autism-related neuroanatomy. Further, leveraging the spatial gene expression data of the Allen Human Brain Atlas, we identified genes whose spatial expression patterns resemble our neuroimaging findings.

Results
In addition to significant main effects for ASD and ADHD in fronto-temporal, limbic, and occipital regions, we observed a significant ASD-by-ADHD interaction in the left precentral gyrus and the right frontal gyrus for measures of CT and SA, respectively. Moreover, individuals with ASD + ADHD differed in CT to those without. Both main effects and the interaction were enriched for ASD—but not for ADHD-related genes.

Limitations
Although we employed a multicenter design to overcome single-site recruitment limitations, our sample size of N = 25 individuals in the ADHD only group is relatively small compared to the other subgroups, which limits the generalizability of the results. Also, we assigned subjects into ADHD positive groupings according to the DSM-5 rating scale. While this is sufficient for obtaining a research diagnosis of ADHD, our approach did not take into account for how long the symptoms have been present, which is typically considered when assessing ADHD in the clinical setting.

Conclusion
Thus, our findings suggest that the neuroanatomy of ASD is significantly modulated by ADHD, and that autistic individuals with co-occurring ADHD may have specific neuroanatomical underpinnings potentially mediated by atypical gene expression.

資料詳細

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言語:
 日付: 2023-10-04
 出版の状態: オンラインで出版済み
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: DOI: 10.1186/s13229-023-00568-z
 学位: -

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出版物 1

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出版物名: Molecular Autism
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: -
ページ: - 巻号: 14 通巻号: 36 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 2040-2392