CerS6-dependent ceramide synthesis in hypothalamic neurons promotes 
ER/mitochondrial stress and impairs glucose homeostasis in obese mice

Hammerschmidt, Philipp; Steculorum, Sophie Marie; Bandet, Cécile L.; Del Rio-Martin, Almudena; Steuernagel, Lukas; Kohlhaas, Vivien; Feldmann, Marvin; Varela, Luis; Majcher, Adam; Quatorze Correia, Marta; Klar, Rhena F.U.; Bauder, Corinna A.; Kaya, Ecem; Porniece, Marta; Biglari, Nasim; Sieben, Anna; Horvath, Tamas L.; Hornemann, Thorsten; Brodesser, Susanne; Brüning, Jens Claus

doi:10.1038/s41467-023-42595-7

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CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice

Hammerschmidt, P., Steculorum, S. M., Bandet, C. L., Del Rio-Martin, A., Steuernagel, L., Kohlhaas, V., et al. (2023). CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice. Nature Communications, 14(1): 7824. doi:10.1038/s41467-023-42595-7.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000E-02D3-1 Version Permalink: https://hdl.handle.net/21.11116/0000-000E-02D4-0

Genre: Journal Article

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Creators:
Hammerschmidt, Philipp¹, Author
Steculorum, Sophie Marie², Author
Bandet, Cécile L., Author
Del Rio-Martin, Almudena³, Author
Steuernagel, Lukas⁴, Author
Kohlhaas, Vivien, Author
Feldmann, Marvin, Author
Varela, Luis, Author
Majcher, Adam, Author
Quatorze Correia, Marta, Author
Klar, Rhena F.U., Author
Bauder, Corinna A., Author
Kaya, Ecem, Author
Porniece, Marta, Author
Biglari, Nasim, Author
Sieben, Anna⁵, Author
Horvath, Tamas L., Author
Hornemann, Thorsten, Author
Brodesser, Susanne, Author
Brüning, Jens Claus⁵, Author

Affiliations:
1Neuronal Control of Metabolism, Department Jens Brüning, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149644
2Steculorum – Neurocircuit Wiring and Function, Max Planck Research Groups, Max Planck Institute for Metabolism Research, Max Planck Society, ou_3485597
3Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149640
4Max Planck Institute for Metabolism Research, Brüning Group, Max Planck Society, ou_2149640
5Brüning – Neuronal Control of Metabolism, Department Brüning, Max Planck Institute for Metabolism Research, Max Planck Society, ou_2149644

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Language(s): eng - English

Dates: Date issued: 2023

Publication Status: Issued

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Rev. Type: Peer

Identifiers: DOI: 10.1038/s41467-023-42595-7

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Title: Nature Communications

Abbreviation : Nat. Commun.

Source Genre: Journal

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Publ. Info: London : Nature Publishing Group

Pages: - Volume / Issue: 14 (1) Sequence Number: 7824 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723