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  Lost and Found in Translation: Why Ribosomal Frameshifting Might Be the Next Antiviral Target

Ayyub, S. A. (2023). Lost and Found in Translation: Why Ribosomal Frameshifting Might Be the Next Antiviral Target. Resonance, 28(9), 1391-1400. doi:10.1007/s12045-023-1675-4.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000E-352C-6 Version Permalink: https://hdl.handle.net/21.11116/0000-000E-3558-4
Genre: Journal Article

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s12045-023-1675-4.pdf (Publisher version), 4MB
 
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 Creators:
Ayyub, Shreya Ahana1, Author           
Affiliations:
1Department of Physical Biochemistry, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society, ou_3350156              

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 Abstract: Programmed ribosomal frameshifting (PRF) is a mechanism of recoding that allows the synthesis of multiple proteins from the same mRNA by shifting the translation reading frame. Many viruses, including the medically important HIV and coronaviruses, rely on PRF to increase their coding capacity and modulate appropriate stoichiometric ratios of viral proteins. Therefore, PRF is an attractive target for the development of antiviral therapeutics such as small molecule inhibitors, biomimetic peptides and attenuated viral vaccines.

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Language(s): eng - English
 Dates: 2023-10-02
 Publication Status: Published online
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 Rev. Type: Peer
 Identifiers: DOI: 10.1007/s12045-023-1675-4
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Project name : RIBOSFL
Grant ID : 101023196
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)

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Title: Resonance
  Abbreviation : Reson
Source Genre: Journal
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Publ. Info: Springer
Pages: - Volume / Issue: 28 (9) Sequence Number: - Start / End Page: 1391 - 1400 Identifier: ISSN: 0973-712X
CoNE: https://pure.mpg.de/cone/journals/resource/0973-712X