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Schlagwörter:
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Zusammenfassung:
Programmed ribosomal frameshifting (PRF) is a mechanism of recoding that allows the synthesis of multiple proteins from the same mRNA by shifting the translation reading frame. Many viruses, including the medically important HIV and coronaviruses, rely on PRF to increase their coding capacity and modulate appropriate stoichiometric ratios of viral proteins. Therefore, PRF is an attractive target for the development of antiviral therapeutics such as small molecule inhibitors, biomimetic peptides and attenuated viral vaccines.
