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  From waste to health-supporting molecules: Biosynthesis of natural products from lignin-, plastic- and seaweed-based monomers using metabolically engineered Streptomyces lividans

Seo, K., Shu, W., Rückert-Reed, C., Gerlinger, P., Erb, T. J., Kalinowski, J., et al. (2023). From waste to health-supporting molecules: Biosynthesis of natural products from lignin-, plastic- and seaweed-based monomers using metabolically engineered Streptomyces lividans. Microbial Cell Factories, 22(1): 262. doi:10.1186/s12934-023-02266-0.

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https://doi.org/10.1186/s12934-023-02266-0 (Publisher version)
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OA-Status:
Gold

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 Creators:
Seo, Kyoyoung1, Author
Shu, Wei1, Author
Rückert-Reed, Christian1, Author
Gerlinger, Patrick2, Author           
Erb, Tobias J.2, Author                 
Kalinowski, Jörn1, Author
Wittmann, Christoph1, Author
Affiliations:
1external, ou_persistent22              
2Understanding and Building Metabolism, Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Max Planck Society, ou_3266303              

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 Abstract: Transforming waste and nonfood materials into bulk biofuels and chemicals represents a major stride in creating a sustainable bioindustry to optimize the use of resources while reducing environmental footprint. However, despite these advancements, the production of high-value natural products often continues to depend on the use of first-generation substrates, underscoring the intricate processes and specific requirements of their biosyntheses. This is also true for Streptomyces lividans, a renowned host organism celebrated for its capacity to produce a wide array of natural products, which is attributed to its genetic versatility and potent secondary metabolic activity. Given this context, it becomes imperative to assess and optimize this microorganism for the synthesis of natural products specifically from waste and nonfood substrates.

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Language(s): eng - English
 Dates: 2023
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Microbial Cell Factories
Source Genre: Journal
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Publ. Info: BioMed Central
Pages: - Volume / Issue: 22 (1) Sequence Number: 262 Start / End Page: - Identifier: ISSN: 1475-2859
CoNE: https://pure.mpg.de/cone/journals/resource/111041294029026