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Free keywords:
sulfonium salts; C-H functionalization; directing group; linchpin; palladium catalysis
Abstract:
Directed C–H functionalization reactions are powerful tools
for the rapid and selective syntheses of complex molecules. However,
many existing C–H functionalization reactions require the presence of a
preinstalled directing group that has to be either a part of the molecule
or introduced onto an existing functional group. Here, we report ana-
logues of thianthrene that can also function as directing groups for in-
termediate directed C–H functionalization and thereby permit regiose-
lective 2,4- and 3,4-aromatic C–H difunctionalization of simple arenes
in yields of 22–33% over three steps.
