English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
 Local TagsRelease HistoryDetailsSummary
  Minute-scale oscillatory sequences in medial entorhinal cortex

Cogno, S. G., Obenhaus, H. A., Lautrup, A., Jacobsen, R. I., Clopath, C., Andersson, S. O., et al. (2023). Minute-scale oscillatory sequences in medial entorhinal cortex. Nature. doi:10.1038/s41586-023-06864-1.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-000E-1795-0 Version Permalink: https://hdl.handle.net/21.11116/0000-000E-1796-F
Genre: Journal Article

Files

show Files

Locators

show
hide
Locator:
https://pubmed.ncbi.nlm.nih.gov/38123682/ (Any fulltext)
Description:
-
OA-Status:
Gold

Creators

show
hide
 Creators:
Cogno, Soledad Gonzalo1, Author
Obenhaus, Horst A1, Author
Lautrup, Ane1, Author
Jacobsen, R Irene1, Author
Clopath, Claudia2, Author
Andersson, Sebastian O1, 3, Author
Donato, Flavio 1, 4, Author
Moser, May-Britt 1, Author
Moser, Edvard I 1, Author
Affiliations:
1Kavli Institute for Systems Neuroscience and Centre for Algorithms in the Cortex, Fred Kavli Building, Norwegian University of Science and Technology, Trondheim, Norway. , ou_persistent22              
2Department of Bioengineering, Imperial College London, London, UK., ou_persistent22              
3Max Planck Institute for Brain Research, Max Planck Society, Max-von-Laue-Str. 4, 60438 Frankfurt am Main, DE, ou_2461692              
4Biozentrum Universität Basel, Basel, Switzerland., ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: The medial entorhinal cortex (MEC) hosts many of the brain’s circuit elements for spatial navigation and episodic memory, operations that require neural activity to be organized across long durations of experience1. Whereas location is known to be encoded by spatially tuned cell types in this brain region2,3, little is known about how the activity of entorhinal cells is tied together over time at behaviourally relevant time scales, in the second-to-minute regime. Here we show that MEC neuronal activity has the capacity to be organized into ultraslow oscillations, with periods ranging from tens of seconds to minutes. During these oscillations, the activity is further organized into periodic sequences. Oscillatory sequences manifested while mice ran at free pace on a rotating wheel in darkness, with no change in location or running direction and no scheduled rewards. The sequences involved nearly the entire cell population, and transcended epochs of immobility. Similar sequences were not observed in neighbouring parasubiculum or in visual cortex. Ultraslow oscillatory sequences in MEC may have the potential to couple neurons and circuits across extended time scales and serve as a template for new sequence formation during navigation and episodic memory formation.

Details

show
hide
Language(s): eng - English
 Dates: 2022-05-012023-11-102023-12-20
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41586-023-06864-1
PMID: 38123682
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nature
  Abbreviation : Nature
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238