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  Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration

Sundaram, V. K., Schütza, V., Schröter, N. H., Backhaus, A., Bilsing, A., Joneck, L., et al. (2023). Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration. Cell Metabolism, 35(12), 2136-2152.e9. doi:10.1016/j.cmet.2023.10.017.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000E-1C2C-3 Version Permalink: https://hdl.handle.net/21.11116/0000-000E-1C2D-2
Genre: Journal Article

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 Creators:
Sundaram, Venkat Krishnan, Author
Schütza, Vlad, Author
Schröter, Nele H., Author
Backhaus, Aline, Author
Bilsing, Annika, Author
Joneck, Lisa, Author
Seelbach, Anna, Author
Mutschler, Clara, Author
Gomez-Sanchez, Jose A., Author
Schäffner, Erik, Author
Sánchez, Eva Ernst, Author
Akkermann, Dagmar, Author
Paul, Christina, Author
Schwagarus, Nancy, Author
Müller, Silvana, Author
Odle, Angela, Author
Childs, Gwen, Author
Ewers, David1, Author           
Kungl, Theresa, Author
Sitte, Maren, Author
Salinas, Gabriela, AuthorSereda, Michael Werner2, Author           Nave, Klaus-Armin1, Author           Schwab, Markus H., AuthorOst, Mario, AuthorArthur-Farraj, Peter, AuthorStassart, Ruth M., AuthorFledrich, Robert, Author more..
Affiliations:
1Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society, ou_3350301              
2Research Group of Translational Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society, ou_3350308              

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 Abstract: The peripheral nervous system harbors a remarkable potential to regenerate after acute nerve trauma. Full functional recovery, however, is rare and critically depends on peripheral nerve Schwann cells that orchestrate breakdown and resynthesis of myelin and, at the same time, support axonal regrowth. How Schwann cells meet the high metabolic demand required for nerve repair remains poorly understood. We here report that nerve injury induces adipocyte to glial signaling and identify the adipokine leptin as an upstream regulator of glial metabolic adaptation in regeneration. Signal integration by leptin receptors in Schwann cells ensures efficient peripheral nerve repair by adjusting injury-specific catabolic processes in regenerating nerves, including myelin autophagy and mitochondrial respiration. Our findings propose a model according to which acute nerve injury triggers a therapeutically targetable intercellular crosstalk that modulates glial metabolism to provide sufficient energy for successful nerve repair.

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Language(s): eng - English
 Dates: 2023-11-202023-12-05
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.cmet.2023.10.017
 Degree: -

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Project name : AxoMyoGlia
Grant ID : 948857
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)
Project name : This work is supported by the DFG with R.F. holding an Emmy Noether fellowship (FL 1025/1-1). R.M.S. holds an ERC starting grant (948857, AxoMyoGlia). This work was funded by the German Research Foundation (DFG) through SFB 1052, project number 209933838, subproject C10 (PIs R.F. and R.M.S). P.A.-F. was supported by the Wellcome Trust (206634/Z/17/Z; for the purpose of open access, this author has applied a CC BY public copyright license to any author accepted manuscript version arising from this submission.), and C.M. was supported by the Medical Research Council (studentship 2251399). J.A.G.-S. is supported by a Miguel Servet Fellowship from the Spanish Health Institute Carlos III (CP22/00078); K.-A.N. holds an ERC advanced grant. The National Institute of Health (NIH) supported G.C. and A.O. (R01 HD059056, R03 HD05966, R01 HD-087057, and Center grants NIGMS P20 GM103425 and P30 GM11070).
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Title: Cell Metabolism
  Other : Cell Metabolism
Source Genre: Journal
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Publ. Info: Cambridge, MA : Cell Press
Pages: - Volume / Issue: 35 (12) Sequence Number: - Start / End Page: 2136 - 2152.e9 Identifier: ISSN: 1550-4131
CoNE: https://pure.mpg.de/cone/journals/resource/111088195284928