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  Distinct effects of AMPAR subunit depletion on spatial memory

Eltokhi, A., Bertocchi, I., Rozov, A., Jensen, V., Borchardt, T., Taylor, A., et al. (2023). Distinct effects of AMPAR subunit depletion on spatial memory. iScience, 26(11): 108116, pp. 1-24. doi:10.1016/j.isci.2023.108116.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000E-2678-1 Version Permalink: https://hdl.handle.net/21.11116/0000-000E-2679-0
Genre: Journal Article

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 Creators:
Eltokhi, Ahmed1, Author           
Bertocchi, Ilaria1, Author           
Rozov, Andrej1, Author           
Jensen, Vidar, Author
Borchardt, Thilo1, Author           
Taylor, Amy, Author
Proenca, Catia C.1, Author           
Rawlins, John Nick P., Author
Bannerman, David M., Author
Sprengel, Rolf1, Author           
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: Pharmacological studies established a role for AMPARs in the mammalian forebrain in spatial memory performance. Here we generated global GluA1/3 double knockout mice (Gria1/3-/-) and conditional knockouts lacking GluA1 and GluA3 AMPAR subunits specifically from principal cells across the forebrain (Gria1/3ΔFb). In both models, loss of GluA1 and GluA3 resulted in reduced hippocampal GluA2 and increased levels of the NMDAR subunit GluN2A. Electrically-evoked AMPAR-mediated EPSPs were greatly diminished, and there was an absence of tetanus-induced LTP. Gria1/3-/- mice showed premature mortality. Gria1/3ΔFb mice were viable, and their memory performance could be analyzed. In the Morris water maze (MWM), Gria1/3ΔFb mice showed profound long-term memory deficits, in marked contrast to the normal MWM learning previously seen in single Gria1-/- and Gria3-/- knockout mice. Our results suggest a redundancy of function within the pool of available ionotropic glutamate receptors for long-term spatial memory performance.
 Abstract: Cellular neuroscience; Molecular neuroscience

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Language(s): eng - English
 Dates: 2023-11-172023-10-01
 Publication Status: Issued
 Pages: 25
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.isci.2023.108116
URI: https://pubmed.ncbi.nlm.nih.gov/37876813/
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Title: iScience
Source Genre: Journal
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Publ. Info: Amsterdam ; Bosten ; London ; New York ; Oxford ; Paris ; Philadelphia ; San Diego ; St. Louis : Elsevier
Pages: - Volume / Issue: 26 (11) Sequence Number: 108116 Start / End Page: 1 - 24 Identifier: ISSN: 2589-0042
CoNE: https://pure.mpg.de/cone/journals/resource/2589-0042