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  Phosphates as assisting groups in glycan synthesis

Sletten, E. T., Fittolani, G., Hribernik, N., Dal Colle, M., Seeberger, P. H., & Delbianco, M. (2024). Phosphates as assisting groups in glycan synthesis. ACS Central Science, 10(1), 138-142. doi:10.1021/acscentsci.3c00896.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000E-29E2-5 Version Permalink: https://hdl.handle.net/21.11116/0000-000E-5416-B
Genre: Journal Article

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 Creators:
Sletten, Eric T.1, Author           
Fittolani, Giulio2, Author           
Hribernik, Nives2, Author                 
Dal Colle, Marlene2, Author           
Seeberger, Peter H.1, Author                 
Delbianco, Martina2, Author                 
Affiliations:
1Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              
2Martina Delbianco, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2559692              

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 Abstract: In nature, phosphates are added to and cleaved from molecules to direct biological pathways. The concept was adapted to overcome limitations in the chemical synthesis of complex oligosaccharides. Phosphates were chemically placed on synthetic glycans to ensure site-specific enzymatic elongation by sialylation. In addition, the deliberate placement of phosphates helped to solubilize and isolate aggregating glycans. Upon traceless removal of the phosphates by enzymatic treatment with alkaline phosphatase, the native glycan structure was revealed, and the assembly of glycan nanostructures was triggered.

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Language(s): eng - English
 Dates: 2023-12-202024
 Publication Status: Issued
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 Identifiers: DOI: 10.1021/acscentsci.3c00896
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Title: ACS Central Science
  Abbreviation : ACS Cent. Sci.
Source Genre: Journal
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Publ. Info: Washington : American Chemical Society
Pages: - Volume / Issue: 10 (1) Sequence Number: - Start / End Page: 138 - 142 Identifier: ISSN: 2374-7951