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  Whole-animal connectome and cell-type complement of the three-segmented Platynereis dumerilii larva

Verasztó, C., Jasek, S., Gühmann, M., Shahidi, R., Ueda, N., Beard, J., et al. (submitted). Whole-animal connectome and cell-type complement of the three-segmented Platynereis dumerilii larva.

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 Creators:
Verasztó, C, Author                 
Jasek, S, Author
Gühmann, M1, Author                 
Shahidi, R, Author                 
Ueda, N1, Author                 
Beard, JD, Author
Mendes, S1, Author           
Heinz, K, Author
Bezares-Calderón, LA, Author                 
Williams, E, Author                 
Jékely, G, Author                 
Affiliations:
1Research Group Neurobiology of Marine Zooplankton, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3379109              

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 Abstract: Nervous systems coordinate effectors across the body during movements. We know little about the cellular-level structure of synaptic circuits for such body-wide control. Here we describe the whole-body synaptic connectome and cell-type complement of a three-segmented larva of the marine annelid Platynereis dumerilii. We reconstructed and annotated over 1,500 neurons and 6,500 non-neuronal cells in a whole-body serial electron microscopy dataset. The differentiated cells fall into 180 neuronal and 90 non-neuronal cell types. We analyse the modular network architecture of the entire nervous system and describe polysynaptic pathways from 428 sensory neurons to four effector systems – ciliated cells, glands, pigment cells and muscles. The complete somatic musculature and its innervation will be described in a companion paper. We also investigated intersegmental differences in cell-type complement, descending and ascending pathways, and mechanosensory and peptidergic circuits. Our work provides the basis for understanding whole-body coordination in annelids.

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 Dates: 2020-08
 Publication Status: Submitted
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1101/2020.08.21.260984
 Degree: -

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