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  Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice

du Halgouet, A., Bruder, K., Peltokangas, N., Darbois, A., Obwegs, D., Salou, M., et al. (2024). Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice. Nature Immunology. doi:10.1038/s41590-023-01710-y.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000E-399F-0 Version Permalink: https://hdl.handle.net/21.11116/0000-000E-39A0-D
Genre: Journal Article

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10.1038_s41590-023-01710-y.pdf (Publisher version), 19MB
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 Creators:
du Halgouet, Anastasia1, Author
Bruder, Kerstin1, Author
Peltokangas, Nina2, Author
Darbois, Aurélie1, Author
Obwegs, David1, Author
Salou, Marion1, Author
Thimme, Robert1, Author
Hofmann, Maike1, Author
Lantz, Olivier1, Author
Sagar1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243642              

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 Abstract: γδ T cells perform heterogeneous functions in homeostasis and disease across tissues. However, it is unclear whether these roles correspond to distinct γδ subsets or to a homogeneous population of cells exerting context-dependent functions. Here, by cross-organ multimodal single-cell profiling, we reveal that various mouse tissues harbor unique site-adapted γδ subsets. Epidermal and intestinal intraepithelial γδ T cells are transcriptionally homogeneous and exhibit epigenetic hallmarks of functional diversity. Through parabiosis experiments, we uncovered cellular states associated with cytotoxicity, innate-like rapid interferon-γ production and tissue repair functions displaying tissue residency hallmarks. Notably, our observations add nuance to the link between interleukin-17-producing γδ T cells and tissue residency. Moreover, transcriptional programs associated with tissue-resident γδ T cells are analogous to those of CD8+ tissue-resident memory T cells. Altogether, this study provides a multimodal landscape of tissue-adapted γδ T cells, revealing heterogeneity, lineage relationships and their tissue residency program.

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Language(s): eng - English
 Dates: 2024-01-04
 Publication Status: Published online
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 Identifiers: DOI: 10.1038/s41590-023-01710-y
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Title: Nature Immunology
  Other : Nat. Immunol.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1529-2908
CoNE: https://pure.mpg.de/cone/journals/resource/974392607073