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  Pathway-selective optogenetics reveals the functional anatomy of top-down attentional modulation in the macaque visual cortex

Hüer, J., Saxena, P., & Treue, S. (2024). Pathway-selective optogenetics reveals the functional anatomy of top-down attentional modulation in the macaque visual cortex. Proceedings of the National Academy of Sciences, 121(3): e2304511121. doi:10.1073/pnas.2304511121.

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Hueer_2024_Pathway-selectiveOptogenetics.pdf (Publisher version), 439KB
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Hueer_2024_Pathway-selectiveOptogenetics.pdf
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Copyright © 2024 the Author(s). Published by PNAS. This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Hüer, Janina1, 2, Author
Saxena, Pankhuri, Author
Treue, Stefan, Author
Affiliations:
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstr. 46, 60528 Frankfurt, DE, ou_2074314              
2Fries Lab, Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstraße 46, 60528 Frankfurt, DE, ou_3381216              

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Free keywords: FRONTAL EYE FIELD SPATIAL ATTENTION TARGET ENHANCEMENT DISTRACTOR SUPPRESSION MOTION PROCESSING
 Abstract: Spatial attention represents a powerful top–down influence on sensory responses in primate visual cortical areas. The frontal eye field (FEF) has emerged as a key candidate area for the source of this modulation. However, it is unclear whether the FEF exerts its effects via its direct axonal projections to visual areas or indirectly through other brain areas and whether the FEF affects both the enhancement of attended and the suppression of unattended sensory responses. We used pathway-selective optogenetics in rhesus macaques performing a spatial attention task to inhibit the direct input from the FEF to area MT, an area along the dorsal visual pathway specialized for the processing of visual motion information. Our results show that the optogenetic inhibition of the FEF input specifically reduces attentional modulation in MT by about a third without affecting the neurons’ sensory response component. We find that the direct FEF-to-MT pathway contributes to both the enhanced processing of target stimuli and the suppression of distractors. The FEF, thus, selectively modulates firing rates in visual area MT, and it does so via its direct axonal projections.

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 Dates: 2024-01-092024-01-16
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: DOI: 10.1073/pnas.2304511121
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Title: Proceedings of the National Academy of Sciences
Source Genre: Journal
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Pages: - Volume / Issue: 121 (3) Sequence Number: e2304511121 Start / End Page: - Identifier: ISSN: 0027-8424
ISSN: 1091-6490