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  Functional host-specific adaptation of the intestinal microbiome in hominids

Rühlemann, M. C., Bang, C., Gogarten, J. F., Hermes, B. M., Groussin, M., Waschina, S., et al. (2024). Functional host-specific adaptation of the intestinal microbiome in hominids. Nature Communications, 15(1): 326. doi:10.1038/s41467-023-44636-7.

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 Creators:
Rühlemann, M. C., Author
Bang, C., Author
Gogarten, J. F., Author
Hermes, B. M., Author
Groussin, M., Author
Waschina, S., Author
Poyet, M., Author
Ulrich, M., Author
Akoua-Koffi, C., Author
Deschner, T., Author
Muyembe-Tamfum, J. J., Author
Robbins, M. M.1, Author                 
Surbeck, M., Author
Wittig , R. M., Author
Zuberbühler, K., Author
Baines, J. F., Author
Leendertz, F. H., Author
Franke, A., Author
Affiliations:
1Department of Primate Behavior and Evolution, Max Planck Institute for Evolutionary Anthropology, Max Planck Society, ou_3367832              

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Free keywords: animals, gastrointestinal microbiome, hominidae, microbiota, Pan paniscus, Pan troglodytes
 Abstract: Fine-scale knowledge of the changes in composition and function of the human gut microbiome compared that of our closest relatives is critical for understanding the evolutionary processes underlying its developmental trajectory. To infer taxonomic and functional changes in the gut microbiome across hominids at different timescales, we perform high-resolution metagenomic-based analyzes of the fecal microbiome from over two hundred samples including diverse human populations, as well as wild-living chimpanzees, bonobos, and gorillas. We find human-associated taxa depleted within non-human apes and patterns of host-specific gut microbiota, suggesting the widespread acquisition of novel microbial clades along the evolutionary divergence of hosts. In contrast, we reveal multiple lines of evidence for a pervasive loss of diversity in human populations in correlation with a high Human Development Index, including evolutionarily conserved clades. Similarly, patterns of co-phylogeny between microbes and hosts are found to be disrupted in humans. Together with identifying individual microbial taxa and functional adaptations that correlate to host phylogeny, these findings offer insights into specific candidates playing a role in the diverging trajectories of the gut microbiome of hominids. We find that repeated horizontal gene transfer and gene loss, as well as the adaptation to transient microaerobic conditions appear to have played a role in the evolution of the human gut microbiome.

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Language(s): eng - English
 Dates: 2024-01-062024
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41467-023-44636-7
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Title: Nature Communications
Source Genre: Journal
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Pages: - Volume / Issue: 15 (1) Sequence Number: 326 Start / End Page: - Identifier: ISBN: 2041-1723