English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
 Local TagsRelease HistoryDetailsSummary
  Continuous flow synthesis of the ionizable lipid ALC-0315

Wolf, J., Lee, J. W., Plutschack, M. B., Cambié, D., Seidel-Morgenstern, A., & Seeberger, P. H. (2024). Continuous flow synthesis of the ionizable lipid ALC-0315. Reaction chemistry & engineering, 9(4), 959-966. doi:10.1039/D3RE00630A.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-000E-4DE4-B Version Permalink: https://hdl.handle.net/21.11116/0000-000F-22B9-A
Genre: Journal Article

Files

show Files
hide Files
:
Article.pdf (Publisher version), 2MB
View   Save
File Permalink:
https://hdl.handle.net/21.11116/0000-000F-22BA-9
Name:
Article.pdf
Description:
-
OA-Status:
Hybrid
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
View
Copyright Date:
-
Copyright Info:
-
License:
http://creativecommons.org/licenses/by/3.0/

Locators

show

Creators

show
hide
 Creators:
Wolf, Jakob1, Author           
Lee, Ju Weon, Author
Plutschack, Matthew B.1, Author           
Cambié, Dario1, Author                 
Seidel-Morgenstern, Andreas, Author
Seeberger, Peter H.2, Author                 
Affiliations:
1Dario Cambié, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_3256668              
2Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              

Content

show
hide
Free keywords: -
 Abstract: The ionizable lipid ALC-0315 is the major component of the lipid nanoparticles used to encapsulate the mRNA in the Biontech–Pfizer COVID-19 vaccine. In early 2021, difficulties encountered in scaling up the production and purification of this lipid impeded vaccine manufacturing, leading to delays in vaccination campaigns designed to combat the global coronavirus pandemic. Flow chemistry has impacted synthetic capabilities on all scales. This work describes a proof of principle continuous flow process comprised of four telescoped steps for the production of ALC-0315 with an overall yield of 20% and a productivity of 7 mmol per hour.

Details

show
hide
Language(s): eng - English
 Dates: 2024-01-082024
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1039/D3RE00630A
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Reaction chemistry & engineering
  Abbreviation : React. Chem. Eng.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cambridge : Royal Society of Chemistry
Pages: - Volume / Issue: 9 (4) Sequence Number: - Start / End Page: 959 - 966 Identifier: ISSN: 2058-9883