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  CSF and venous blood flow from childhood to adulthood studied by real-time phase-contrast MRI

Sahoo, P., Kollmeier, J. M., Wenkel, N., Badura, S., Gaertner, J., Frahm, J., & Dreha-Kulaczewski, S. (2024). CSF and venous blood flow from childhood to adulthood studied by real-time phase-contrast MRI. Childs Nervous System, 40, 1377-1388. doi:10.1007/s00381-024-06275-1.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-000E-66B9-F 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000F-7AA1-2
資料種別: 学術論文

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s00381-024-06275-1.pdf (出版社版), 2MB
ファイルのパーマリンク:
https://hdl.handle.net/21.11116/0000-000E-66BB-D
ファイル名:
s00381-024-06275-1.pdf
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Hybrid
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公開
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application/pdf / [MD5]
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作成者

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 作成者:
Sahoo, Prativa, 著者
Kollmeier, Jost Michael1, 著者           
Wenkel, Nora, 著者
Badura, Simon, 著者
Gaertner, Jutta, 著者
Frahm, Jens1, 著者           
Dreha-Kulaczewski, Steffi, 著者
所属:
1Research Group Biomedical NMR, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society, ou_3350294              

内容説明

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 要旨: Purpose
In vivo measurements of CSF and venous flow using real-time phase-contrast (RT-PC) MRI facilitate new insights into the dynamics and physiology of both fluid systems. In clinical practice, however, use of RT-PC MRI is still limited. Because many forms of hydrocephalus manifest in infancy and childhood, it is a prerequisite to investigate normal flow parameters during this period to assess pathologies of CSF circulation. This study aims to establish reference values of CSF and venous flow in healthy subjects using RT-PC MRI and to determine their age dependency.

Methods
RT-PC MRI was performed in 44 healthy volunteers (20 females, age 5–40 years). CSF flow was quantified at the aqueduct (Aqd), cervical (C3) and lumbar (L3) spinal levels. Venous flow measurements comprised epidural veins, internal jugular veins and inferior vena cava. Parameters analyzed were peak velocity, net flow, pulsatility, and area of region of interest (ROI). Statistical tests: linear regression, student's t-test and analysis of variance (ANOVA).

Results
In adults volunteers, no significant changes in flow parameters were observed. In contrast, pediatric subjects exhibited a significant age-dependent decrease of CSF net flow and pulsatility in Aqd, C3 and L3. Several venous flow parameters decreased significantly over age at C3 and changed more variably at L3.

Conclusion
Flow parameters varies depending on anatomical location and age. We established changes of brain and spinal fluid dynamics over an age range from 5–40 years. The application of RT-PC MRI in clinical care may improve our understanding of CSF flow pathology in individual patients.

資料詳細

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言語: eng - English
 日付: 2024-01-112024-05
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子(DOI, ISBNなど): DOI: 10.1007/s00381-024-06275-1
 学位: -

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出版物 1

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出版物名: Childs Nervous System
  その他 : Childs Nerv. Syst.
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: Heidelberg : Springer
ページ: - 巻号: 40 通巻号: - 開始・終了ページ: 1377 - 1388 識別子(ISBN, ISSN, DOIなど): ISSN: 0256-7040
CoNE: https://pure.mpg.de/cone/journals/resource/954927648745