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  Kidins220 regulates the development of B cells bearing the λ light chain

Schaffer, A.-M., Fiala, G. J., Hils, M., Natali, E., Babrak, L., Herr, L. A., et al. (2024). Kidins220 regulates the development of B cells bearing the λ light chain. eLife, 13: e83943. doi:10.7554/eLife.83943.

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10.7554_eLife.83943.pdf (Publisher version), 4MB
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Schaffer et al.

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https://elifesciences.org/articles/83943 (Publisher version)
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 Creators:
Schaffer, Anna-Maria1, Author
Fiala, Gina Jasmin1, Author
Hils, Miriam1, Author
Natali, Eriberto1, Author
Babrak, Lmar1, Author
Herr, Laurenz Alexander1, Author
Romero-Mulero, Mari Carmen2, Author
Cabezas-Wallscheid, Nina2, Author           
Rizzi, Marta1, Author
Miho, Enkelejda1, Author
Schamel, Wolfgang W A1, Author
Minguet, Susana1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              

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Free keywords: B cells; adaptive immunity; immunology; inflammation; lambda light chain; mouse; recombination; signalling.
 Abstract: The ratio between κ and λ light chain (LC)-expressing B cells varies considerably between species. We recently identified Kinase D-interacting substrate of 220 kDa (Kidins220) as an interaction partner of the BCR. In vivo ablation of Kidins220 in B cells resulted in a marked reduction of λLC-expressing B cells. Kidins220 knockout B cells fail to open and recombine the genes of the Igl locus, even in genetic scenarios where the Igk genes cannot be rearranged or where the κLC confers autoreactivity. Igk gene recombination and expression in Kidins220-deficient B cells is normal. Kidins220 regulates the development of λLC B cells by enhancing the survival of developing B cells and thereby extending the time-window in which the Igl locus opens and the genes are rearranged and transcribed. Further, our data suggest that Kidins220 guarantees optimal pre-BCR and BCR signaling to induce Igl locus opening and gene recombination during B cell development and receptor editing.

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Language(s): eng - English
 Dates: 2024-01-25
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.7554/eLife.83943
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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 13 Sequence Number: e83943 Start / End Page: - Identifier: Other: URL
ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X