非表示:
キーワード:
Animals, Apoptosis, bcl-2 Homologous Antagonist-Killer Protein, bcl-2-Associated X Protein, Humans, Mitochondrial Membranes, Phospholipids, Protein Binding, Protein Domains, Protein Multimerization
要旨:
BAX and BAK oligomerize to mediate mitochondrial membrane permeabilization during apoptosis. A recent structure of the core domain of active BAK dimers with bound phospholipid molecules reveals a new bridging mechanism by which lipids drive BAX and BAK oligomerization and membrane pore formation.
