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  Complex sequential learning is not facilitated by transcranial direct current stimulation over DLPFC or M1

Kaminski, E., Carius, D., Knieke, J., Mizuguchi, N., & Ragert, P. (2024). Complex sequential learning is not facilitated by transcranial direct current stimulation over DLPFC or M1. European Journal of Neuroscience, 59(8), 2046-2058. doi:10.1111/ejn.16255.

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Kaminski, Elisabeth1, 2, Author           
Carius, Daniel1, Author
Knieke, Jan1, Author
Mizuguchi, Nobuaki3, 4, Author
Ragert, Patrick1, 2, Author                 
Affiliations:
1Department of Human Movement Neuroscience, Faculty of Sport Science, University of Leipzig, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Research Organization of Science and Technology, Ritsumeikan University, Kyoto, Japan, ou_persistent22              
4Graduate School of Sport and Health Science, Ritsumeikan University, Kyoto, Japan, ou_persistent22              

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Free keywords: Complex serial reaction time task; Dorsolateral prefrontal cortex; Primary motor cortex; Sequential learning; Transcranial direct current stimulation
 Abstract: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique which was found to have a positive modulatory effect on online sequence acquisition or offline motor consolidation, depending on the relative role of the associated brain region. Primary motor regions (M1) and dorsolateral prefrontal cortices (DLPFC) have both been related to sequential learning. However, research so far did not systematically disentangle their differential roles in online and offline learning especially in more complex sequential paradigms. In this study, the influence of anodal M1 leg area-tDCS and anodal DLPFC-tDCS applied during complex sequential learning (online and offline) was investigated using a complex whole body serial reaction time task (CWB-SRTT) in 42 healthy volunteers. TDCS groups did not differ from sham tDCS group regarding their response and reaction time (online) and also not in terms of overnight consolidation (offline). Sequence specific learning and the number of recalled items also did not differ between groups. Results may be related to unspecific parameters such as timing of the stimulation or current intensity but can also be attributed to the relative role of M1 and DLPFC during early complex learning. Taken together, the current study provides preliminary evidence that M1 leg area or DLPFC modulation by means of tDCS does not improve complex sequential skill learning. SIGNIFICANCE STATEMENT: Understanding motor learning is helpful to deepen our knowledge about the human ability to acquire new skills. Complex sequential learning tasks have only been studied, sparsely, but are particularly mimicking challenges of daily living. The present study studied early motor learning in a complex serial reaction time task while transcranial direct current stimulation (tDCS) was either applied to leg primary motor cortex or bilateral dorsolateral prefrontal cortex. TDCS did not affect sequential learning, neither directly during performance nor in terms of sequence consolidation. Results provide preliminary information that M1 or bilateral DLPFC modulation does not improve early complex motor learning.

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Language(s): eng - English
 Dates: 2023-12-192023-08-222024-01-022024-01-252024-04
 Publication Status: Issued
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1111/ejn.16255
Other: epub 2024
PMID: 38270331
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Funding organization : Deutsche Forschungsgemeinschaft (DFG)
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Funding organization : Projekt DEAL

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Title: European Journal of Neuroscience
  Other : EJN
  Other : Eur. J. Neurosci
Source Genre: Journal
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Publ. Info: Hoboken, New Jersey, USA : Wiley
Pages: - Volume / Issue: 59 (8) Sequence Number: - Start / End Page: 2046 - 2058 Identifier: ISSN: 0953-816X
CoNE: https://pure.mpg.de/cone/journals/resource/954925575988