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  Polyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in C. elegans

Peters, L., Drechsler, M., Pees, B., Angelidou, G., Salzer, L., Moors, K. A., et al. (submitted). Polyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in C. elegans.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000E-7655-E Version Permalink: https://hdl.handle.net/21.11116/0000-000E-7656-D
Genre: Paper

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 Creators:
Peters, Lena, Author
Drechsler, Moritz, Author
Pees, Barbara, Author
Angelidou, Georgia, Author
Salzer, Liesa, Author
Moors, Karlis Arturs, Author
Paczia, Nicole, Author
Schulenburg, Hinrich1, Author                 
Shi, Yi-Ming1, Author
Kaleta, Christoph, Author
Witting, Michael, Author
Bode, Helge B., Author
Dierking, Katja, Author
Affiliations:
1Max Planck Fellow Group Antibiotic Resistance Evolution, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2600692              

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 Abstract: Protection against pathogens is a major function of the gut microbiota. Although bacterial natural products have emerged as crucial components of host-microbiota interactions, their exact role in microbiota-mediated protection is largely unexplored. We addressed this knowledge gap with the nematode Caenorhabditis elegans and its microbiota isolate Pseudomonas fluorescens MYb115 that is known to protect against Bacillus thuringiensis (Bt) infection. We find that MYb115-mediated protection depends on sphingolipids that are derived from an iterative type I polyketide synthase (PKS), thereby describing a noncanonical pathway of bacterial sphingolipid production. We provide evidence that MYb115-derived sphingolipids affect C. elegans tolerance to Bt infection by altering host sphingolipid metabolism. This work establishes sphingolipids as structural outputs of bacterial PKS and highlights the role of microbiota-derived sphingolipids in host protection against pathogens.Competing Interest StatementThe authors have declared no competing interest.

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Language(s): eng - English
 Dates: 2024-02-07
 Publication Status: Submitted
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: No review
 Identifiers: DOI: 10.1101/2024.02.06.579051
 Degree: -

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Project name : project A1.2, project A1.1, and project 598 A1.5
Grant ID : -
Funding program : Collaborative Research 597 Center CRC1182 Origin and Function of Metaorganisms
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : P40OD010440
Funding program : Caenorhabditis Genetics Center (University of Minnesota)
Funding organization : NIH Office of Research Infrastructure Programs
Project name : -
Grant ID : 835108
Funding program : ERC advanced grant
Funding organization : European Research Council
Project name : -
Grant ID : -
Funding program : -
Funding organization : Max-Planck Society
Project name : MetClassNet
Grant ID : 431572533
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)

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