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  Intracellular microbial rhodopsin-based optogenetics to control metabolism and cell signaling

Vlasova, A. D., Bukhalovich, S. M., Bagaeva, D. F., Polyakova, A. P., Ilyinsky, N. S., Nesterov, S. V., et al. (2024). Intracellular microbial rhodopsin-based optogenetics to control metabolism and cell signaling. Chemical Society Reviews, 53(7), 3327-3349. doi:10.1039/d3cs00699a.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000E-7738-E Version Permalink: https://hdl.handle.net/21.11116/0000-000F-2089-2
Genre: Journal Article

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 Creators:
Vlasova, Anastasiia D.1, Author
Bukhalovich, Siarhei M.1, Author
Bagaeva, Diana F.1, Author
Polyakova, Aleksandra P.1, Author
Ilyinsky, Nikolay S.1, Author
Nesterov, Semen V.1, Author
Tsybrov, Fedor M.1, Author
Bogorodskiy, Andrey O.1, Author
Zinovev, Egor V.1, Author
Mikhailov, Anatolii E.1, Author
Vlasov, Alexey V.1, 2, Author
Kuklin, Alexander I.1, 2, Author
Borshchevskiy, Valentin I.1, 2, Author
Bamberg, Ernst3, Author           
Uversky, Vladimir N.4, Author
Gordeliy, Valentin I.5, Author
Affiliations:
1Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia, ou_persistent22              
2Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna, Russia, ou_persistent22              
3Emeritusgroup Biophysical Chemistry, Max Planck Institute of Biophysics, Max Planck Society, ou_2253652              
4Department of Molecular Medicine and Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA, ou_persistent22              
5Institut de Biologie Structurale Jean-Pierre Ebel, Université Grenoble Alpes-Commissariat à l'Energie Atomique et aux Energies Alternatives-CNRS, 38027 Grenoble, France, ou_persistent22              

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 Abstract: Microbial rhodopsin (MRs) ion channels and pumps have become invaluable optogenetic tools for neuroscience as well as biomedical applications. Recently, MR-optogenetics expanded towards subcellular organelles opening principally new opportunities in optogenetic control of intracellular metabolism and signaling via precise manipulations of organelle ion gradients using light. This new optogenetic field expands the opportunities for basic and medical studies of cancer, cardiovascular, and metabolic disorders, providing more detailed and accurate control of cell physiology. This review summarizes recent advances in studies of the cellular metabolic processes and signaling mediated by optogenetic tools targeting mitochondria, endoplasmic reticulum (ER), lysosomes, and synaptic vesicles. Finally, we discuss perspectives of such an optogenetic approach in both fundamental and applied research.

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Language(s): eng - English
 Dates: 2023-08-272024-02-232024-02-23
 Publication Status: Issued
 Pages: 25
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1039/d3cs00699a
BibTex Citekey: vlasova_intracellular_2024
 Degree: -

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Title: Chemical Society Reviews
  Other : Chem. Soc. Rev.
Source Genre: Journal
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Affiliations:
Publ. Info: London : Royal Society of Chemistry, etc.
Pages: - Volume / Issue: 53 (7) Sequence Number: - Start / End Page: 3327 - 3349 Identifier: ISSN: 0306-0012
CoNE: https://pure.mpg.de/cone/journals/resource/110992357259182