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  External cues improve visual working memory encoding in the presence of salient distractors in schizophrenia

Barnes-Scheufler, C. V., Rösler, L., Schaum, M., Schiweck, C., Peters, B., Mayer, J. S., et al. (2024). External cues improve visual working memory encoding in the presence of salient distractors in schizophrenia. Psychological Medicine, 1-10. doi:10.1017/S0033291724000059.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000E-9D20-D Versions-Permalink: https://hdl.handle.net/21.11116/0000-000E-9D21-C
Genre: Zeitschriftenartikel

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Barnes-Scheufler_2024_ExternalCues.pdf (Verlagsversion), 347KB
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https://hdl.handle.net/21.11116/0000-000E-9D22-B
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Barnes-Scheufler_2024_ExternalCues.pdf
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Copyright Datum:
2024
Copyright Info:
© The Author(s), 2024. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
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http://creativecommons.org/licenses/by/4.0/

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 Urheber:
Barnes-Scheufler, Catherine V., Autor
Rösler, Lara, Autor
Schaum, Michael, Autor
Schiweck, Carmen, Autor
Peters, Benjamin, Autor
Mayer, Jutta S., Autor
Reif, Andreas, Autor
Wibral, Michael, Autor
Bittner, Robert A.1, 2, Autor
Affiliations:
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstr. 46, 60528 Frankfurt, DE, ou_2074314              
2Singer Lab, Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstraße 46, 60528 Frankfurt, DE, ou_3381220              

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Schlagwörter: attention cognitive dysfunction schizophrenia working memory
 Zusammenfassung: Background
People with schizophrenia (PSZ) are impaired in attentional prioritization of non-salient but relevant stimuli over salient distractors during visual working memory (VWM) encoding. Conversely, guidance of top–down attention by external predictive cues is intact. Yet, it is unknown whether this preserved ability can help PSZ encode more information in the presence of salient distractors.

Methods
We employed a visuospatial change-detection task using four Gabor patches with differing orientations in 66 PSZ and 74 healthy controls (HCS). Two Gabor patches flickered which were designated either as targets or distractors and either a predictive or a non-predictive cue was displayed to manipulate top–down attention, resulting in four conditions.

Results
We observed significant effects of group, salience and cue as well as significant interactions of salience by cue, group by salience and group by cue. Across all conditions, PSZ stored significantly less information in VWM than HCS. PSZ stored significantly less non-flickering than flickering information with a non-predictive cue. However, PSZ stored significantly more flickering and non-flickering information with a predictive cue.

Conclusions
Our findings indicate that control of attentional selection is impaired in schizophrenia. We demonstrate that additional top–down information significantly improves performance in PSZ. The observed deficit in attentional control suggests a disturbance of GABAergic inhibition in early visual areas. Moreover, our findings are indicative of a mechanism for enhancing attentional control in PSZ, which could be utilized by pro-cognitive interventions. Thus, the current paradigm is suitable to reveal both preserved and compromised cognitive component processes in schizophrenia.

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 Datum: 2024-03-042024
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1017/S0033291724000059
 Art des Abschluß: -

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Titel: Psychological Medicine
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: - Artikelnummer: - Start- / Endseite: 1 - 10 Identifikator: ISSN: 0033-2917
ISSN: 1469-8978