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Abstract:
The SnCl4-catalyzed CC-Coupling of tertiary alkyl halides (1) with trimethyl-silyl cyanide (2) is of preparative interest; the resulting nitriles (3) can be modified in a number of ways, e.g. by Grignard reaction or reduction. Since the educts (1) are accessible from ketones, the geminal dialkylation of ketones is thus possible.