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  The interplay between nutrition and the dynamics of the midgut microbiome of the mosquito Aedes aegypti reveals putative symbionts

Salgado, J. F. M., Premkrishnan, B. N. V., Oliveira, E. L., Vettath, V. K., Goh, F. G., Hou, X., et al. (2024). The interplay between nutrition and the dynamics of the midgut microbiome of the mosquito Aedes aegypti reveals putative symbionts. bioRxiv: the preprint server for biology, 2024.03.04.583003.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000E-A649-5 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000F-68E8-7
Genre: Preprint

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https://doi.org/10.1101/2024.03.04.583003 (Preprint)
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 Urheber:
Salgado, João Felipe M.1, Autor
Premkrishnan, Balakrishnan N. V.2, Autor
Oliveira, Elaine L.2, Autor
Vettath, Vineeth Kodengil2, Autor
Goh, Feng Guang2, Autor
Hou, Xinjun2, Autor
Drautz-Moses, Daniela I.2, Autor
Cai, Yu2, Autor
Schuster, Stephan C.2, Autor
Junqueira, Ana Carolina M.2, Autor
Affiliations:
1Max Planck Institute for Terrestrial Microbiology_others, Max Planck Institute for Terrestrial Microbiology, Max Planck Society, Karl-von Frisch Str. 10, 35043 Marburg, Germany, ou_3556424              
2external, ou_persistent22              

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 Zusammenfassung: Blood meals are crucial for the reproductive cycle of Aedes aegypti and represent the means by which arboviruses are transmitted to its hematophagy hosts. It also has been postulated that feeding on blood may modulate the mosquito microbiome, but the compositional shifts in microbial diversity and function remain elusive. In this paper, we analyzed the modulation of the midgut microbiome in 60 females of Aedes aegypti throughout the digestive period, 12, 24, and 48 hours after blood or sugar meals using whole-genome shotgun sequencing. Microbial transstadial transmission between larvae and adults was also assessed. This approach provided a high coverage of the midgut metagenome, allowing microbial taxonomic assignments at the species level and gene-based functional profiling. Females at later hours post-feeding and larvae display low microbiome diversities and little evidence of transstadial transmission. However, a striking proliferation of Enterobacterales was observed during early hours of digestion in blood-fed mosquitoes. The compositional shift was concomitant with a predicted functional change in genes associated with carbohydrate and protein metabolism. The observed shifts in blood-fed females’ midguts are restored to a sugar-fed-like microbial profile after 48h, when blood digestion is completed. Conversely, as in all blood-fed females, a high abundance of the opportunistic human pathogen Elizabethkingia anophelis (Flavobacteriales) takes place in this post-digestion stage. This bacterial species has also been described as a symbiont of mosquitoes of the genus Anopheles (Culicidae). This work is the first report of the adaptation of the midgut microbiome of A. aegypti to a digestive role after a blood meal, at the expense of the proliferation of potential symbionts.Significance statement The findings in this paper can contribute to a better understanding of the dynamics of the mosquito microbiome during digestion and its potential implications for host physiology and metabolism, also informing the future development of sustainable methods for insect-borne diseases control based on microbial components that might influence vectorial capacity and pathogen transmission by A. aegypti.Competing Interest StatementThe authors have declared no competing interest.

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Sprache(n): eng - English
 Datum: 2024-03-04
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Keine Begutachtung
 Identifikatoren: URI: http://biorxiv.org/content/early/2024/03/04/2024.03.04.583003.abstract
DOI: 10.1101/2024.03.04.583003
bioRxiv: 10.1101/2024.03.04.583003
 Art des Abschluß: -

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Titel: bioRxiv : the preprint server for biology
  Kurztitel : bioRxiv
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: - Artikelnummer: 2024.03.04.583003 Start- / Endseite: - Identifikator: ZDB: 2766415-6
CoNE: https://pure.mpg.de/cone/journals/resource/2766415-6