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  One more for light-triggered conformational changes in cryptochromes: CryP from Phaeodactylum tricornutum

Saft, M., Schneider, L., Ho, C.-C., Maiterth, E., Menke, J., Sendker, F., et al. (2024). One more for light-triggered conformational changes in cryptochromes: CryP from Phaeodactylum tricornutum. Journal of Molecular Biology, 436(5). doi:10.1016/j.jmb.2023.168408.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000E-A64F-F Versions-Permalink: https://hdl.handle.net/21.11116/0000-000F-2ABD-E
Genre: Zeitschriftenartikel
Alternativer Titel : Photosensory Receptors-Mechanisms and Effects

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externe Referenz:
https://doi.org/10.1016/j.jmb.2023.168408 (Verlagsversion)
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Hybrid

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 Urheber:
Saft, Martin1, Autor
Schneider, Leonie1, Autor
Ho, Chun-Chih1, Autor
Maiterth, Elias1, Autor
Menke, Josephine1, Autor
Sendker, Franziska2, Autor
Steinchen, Wieland1, Autor
Essen, Lars-Oliver1, Autor
Affiliations:
1external, ou_persistent22              
2Max Planck Institute for Terrestrial Microbiology_others, Max Planck Institute for Terrestrial Microbiology, Max Planck Society, Karl-von Frisch Str. 10, 35043 Marburg, Germany, ou_3556424              

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Schlagwörter: cryptochrome, FAD, HDX-MS, photoreceptor, photobiology
 Zusammenfassung: Cryptochromes are a ubiquitously occurring class of photoreceptors. Together with photolyases, they form the Photolyase Cryptochrome Superfamily (PCSf) by sharing a common protein architecture and binding mode of the FAD chromophore. Despite these similarities, PCSf members exert different functions. Photolyases repair UV-induced DNA damage by photocatalytically driven electron transfer between FADH¯ and the DNA lesion, whereas cryptochromes are light-dependent signaling molecules and trigger various biological processes by photoconversion of their FAD redox and charge states. Given that most cryptochromes possess a C-terminal extension (CTE) of varying length, the functions of their CTE have not yet been fully elucidated and are hence highly debated. In this study, the role of the CTE was investigated for a novel subclass of the PCSf, the CryP-like cryptochromes, by hydrogen/deuterium exchange and mass-spectrometric analysis. Striking differences in the relative deuterium uptake were observed in different redox states of CryP from the diatom Phaeodactylum tricornutum. Based on these measurements we propose a model for light-triggered conformational changes in CryP-like cryptochromes that differs from other known cryptochrome families like the insect or plant cryptochromes.

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Sprache(n): eng - English
 Datum: 2024-03-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: URI: https://www.sciencedirect.com/science/article/pii/S0022283623005259
DOI: 10.1016/j.jmb.2023.168408
 Art des Abschluß: -

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Quelle 1

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Titel: Journal of Molecular Biology
  Andere : JMB
  Kurztitel : J. Mol. Biol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Elsevier
Seiten: 168408 Band / Heft: 436 (5) Artikelnummer: - Start- / Endseite: - Identifikator: ISSN: 0022-2836
CoNE: https://pure.mpg.de/cone/journals/resource/0022-2836

Quelle 2

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Titel: Photosensory Receptors-Mechanisms and Effects
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 436 (5) Artikelnummer: 168408 Start- / Endseite: - Identifikator: ISBN: 0022-2836