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Abstract:
The evolutionarily conserved Crumbs protein complex, initially identified in Drosophila, is a crucial regulator of epithelial cell polarity and shape in both invertebrates and vertebrates. Mutations are associated with various diseases, which are based on epithelial dysfunction, such as tumorigenesis, and result in retinal degeneration in humans, mice and flies. The plethora of its interaction partner defines the Crumbs complex as an apical hub to coordinate polarity, adhesion and signalling.
