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  A shifting role of thalamocortical connectivity in the emergence of cortical functional organization

Park, S., Haak, K. V., Oldham, S., Cho, H., Byeon, K., Park, B.-y., Thomson, P., Chen, H., Gao, W., Xu, T., Valk, S. L., Milham, M., Bernhardt, B., Martino, A. D., & Hong, S.-J. (2024). A shifting role of thalamocortical connectivity in the emergence of cortical functional organization. Nature Neuroscience. doi:10.1038/s41593-024-01679-3.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-000E-B1E9-3 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000F-7949-8
資料種別: 学術論文

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Park_pre.pdf (プレプリント), 8MB
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URL:
https://www.biorxiv.org/content/10.1101/2024.03.11.584415v1 (プレプリント)
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作成者

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 作成者:
Park, Shinwon1, 2, 著者
Haak, Koen V.3, 4, 著者
Oldham, Stuart5, 6, 著者
Cho, Hanbyul1, 著者
Byeon, Kyoungseob7, 著者
Park, Bo-yong1, 8, 著者
Thomson, Phoebe2, 著者
Chen, Haitao9, 10, 著者
Gao, Wei9, 11, 著者
Xu, Ting7, 著者
Valk, Sofie L.12, 13, 著者                 
Milham, Michael7, 14, 著者
Bernhardt, Boris15, 著者
Martino, Adriana Di2, 著者
Hong, Seok-Jun1, 7, 16, 17, 18, 著者
所属:
1Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Republic of Korea, ou_persistent22              
2Autism Center, Child Mind Institute, New York, NY, USA, ou_persistent22              
3Department of Cognitive Science and Artificial Intelligence, Tilburg School of Humanities and Digital Sciences (TSHD), Tilburg University, the Netherlands, ou_persistent22              
4Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
5Developmental Imaging, Murdoch Childrens Research Institute, Melbourne, Australia, ou_persistent22              
6Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia, ou_persistent22              
7Center for the Developing Brain, Child Mind Institute, New York, NY, USA, ou_persistent22              
8Department of Data Science, Inha University, Incheon, Republic of Korea, ou_persistent22              
9Department of Biomedical Sciences, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA, ou_persistent22              
10Department of Bioengineering, University of California, Los Angeles, CA, USA, ou_persistent22              
11Department of Medicine, University of California, Los Angeles, CA, USA, ou_persistent22              
12Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              
13Institute of Neuroscience and Medicine (INM-7), Brain and Behavior, Research Center Jülich, Germany, ou_persistent22              
14Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA, ou_persistent22              
15McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, QC, Canada, ou_persistent22              
16Department of Biomedical Engineering, Sungkyunkwan University, Seoul, Republic of Korea, ou_persistent22              
17Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Seoul, Republic of Korea, ou_persistent22              
18Department of MetaBioHealth, Sungkyunkwan University, Seoul, Republic of Korea, ou_persistent22              

内容説明

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キーワード: Brain; Network models; Neuronal development; Neuroscience
 要旨: The cortical patterning principle has been a long-standing question in neuroscience, yet how this translates to macroscale functional specialization in the human brain remains largely unknown. Here we examine age-dependent differences in resting-state thalamocortical connectivity to investigate its role in the emergence of large-scale functional networks during early life, using a primarily cross-sectional but also longitudinal approach. We show that thalamocortical connectivity during infancy reflects an early differentiation of sensorimotor networks and genetically influenced axonal projection. This pattern changes in childhood, when connectivity is established with the salience network, while decoupling externally and internally oriented functional systems. A developmental simulation using generative network models corroborated these findings, demonstrating that thalamic connectivity contributes to developing key features of the mature brain, such as functional segregation and the sensory-association axis, especially across 12-18 years of age. Our study suggests that the thalamus plays an important role in functional specialization during development, with potential implications for studying conditions with compromised internal and external processing.

資料詳細

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言語: eng - English
 日付: 2023-04-262024-05-132024-06-10
 出版の状態: オンラインで出版済み
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子（DOI, ISBNなど）: DOI: 10.1038/s41593-024-01679-3
その他: online ahead of print
PMID: 38858608
 学位: -

関連イベント

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訴訟

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Project information

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Project name : -
Grant ID : IBS-R015-D1
Funding program : -
Funding organization : Institute for Basic Science
Project name : -
Grant ID : NRF-2022R1C1C1007095; R5-2023-00217361; RS-2024-00398768; NRF-2022R1A5A7033499
Funding program : -
Funding organization : National Research Foundation of Korea (NRF) funded by the Korea Government (MSIT)
Project name : -
Grant ID : 09150171910043
Funding program : -
Funding organization : Dutch Research Council
Project name : -
Grant ID : R01MH115363; 5R01MH133334
Funding program : -
Funding organization : National Institute for Mental Health (NIMH)
Project name : -
Grant ID : NSERC Discovery-1304413
Funding program : -
Funding organization : National Science and Engineering Research Council of Canada (NSERC)
Project name : -
Grant ID : FDN-154298, PJT-174995; PJT-191853
Funding program : -
Funding organization : Canadian Institutes of Health Research (CIHR)
Project name : -
Grant ID : NI17-039
Funding program : -
Funding organization : SickKids Foundation
Project name : -
Grant ID : ACAR-TACC
Funding program : -
Funding organization : Azrieli Center for Autism Research
Project name : -
Grant ID : RF1MH128696; U01DA055366
Funding program : -
Funding organization : National Institutes of Health (NIH)
Project name : -
Grant ID : 2022–0–00448; RS-2022–00155915; 2021–0–02068
Funding program : -
Funding organization : Institute for Information and Communications Technology Planning and Evaluation funded by the Korea Government (MSIT)

出版物 1

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出版物名: Nature Neuroscience
  その他 : Nat. Neurosci.
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: New York, NY : Nature America Inc.
ページ: - 巻号: - 通巻号: - 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931