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  The neurobiology of life course socioeconomic conditions and associated cognitive performance in middle to late adulthood

Schrempft, S., Trofimova, O., Künzi, M., Ramponi, C., Lutti, A., Kherif, F., et al. (2024). The neurobiology of life course socioeconomic conditions and associated cognitive performance in middle to late adulthood. The Journal of Neuroscience, 44(17): e1231232024. doi:10.1523/JNEUROSCI.1231-23.2024.

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Schrempft, Stephanie1, Author
Trofimova, Olga2, 3, 4, Author
Künzi, Morgane5, 6, 7, Author
Ramponi, Cristina2, Author
Lutti, Antoine2, Author
Kherif, Ferath2, Author
Latypova, Adeliya2, Author
Vollenweider, Peter8, Author
Marques-Vidal, Pedro8, Author
Preisig, Martin9, Author
Kliegel, Matthias5, 6, 7, Author
Stringhini, Silvia1, 10, 11, Author
Draganski, Bogdan2, 12, Author           
Affiliations:
1Division of Primary Care, University Hospital of Geneva, Switzerland, ou_persistent22              
2Département des Neurosciences Cliniques, Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
3Department of Computational Biology, University of Lausanne, Switzerland, ou_persistent22              
4Swiss Institute of Bioinformatics, University of Lausanne, Switzerland, ou_persistent22              
5LIVES, Overcoming Vulnerability: Life Course Perspective, Swiss National Centre of Competence in Research, University of Lausanne, Switzerland, ou_persistent22              
6Department of Psychology, University of Geneva, Switzerland, ou_persistent22              
7Centre for the Interdisciplinary Study of Gerontology and Vulnerability (CIGEV), niversity of Geneva, Switzerland, ou_persistent22              
8Department of Medicine, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
9Department of Psychiatry, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
10Department of Health and Community Medicine, University of Geneva, Switzerland, ou_persistent22              
11University Centre for General Medicine and Public Health, University of Lausanne, Switzerland, ou_persistent22              
12Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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 Abstract: Despite major advances, our understanding of the neurobiology of life course socioeconomic conditions is still scarce. This study aimed to provide insight into the pathways linking socioeconomic exposures – household income, last-known occupational position, and life course socioeconomic trajectories – with brain microstructure and cognitive performance in middle to late adulthood. We assessed socioeconomic conditions alongside quantitative relaxometry and diffusion-weighted magnetic resonance imaging indicators of brain tissue microstructure, and cognitive performance in a sample of community-dwelling men and women (N=751, aged 50-91 years). We adjusted the applied regression analyses and structural equation models for the linear and non-linear effects of age, sex, education, cardiovascular risk factors, and presence of depressive, anxiety, and substance use disorders. Individuals from lower income households showed signs of advanced brain white matter aging with greater mean diffusivity, lower neurite density, lower myelination, and lower iron content. The association between household income and mean diffusivity was mediated by neurite density (B=0.084, p=0.003) and myelination (B=0.019, p=0.009); mean diffusivity partially mediated the association between household income and cognitive performance (B=0.017, p<0.05). Household income moderated the relation between white matter microstructure and cognitive performance, such that greater mean diffusivity, lower myelination, or lower neurite density was only associated with poorer cognitive performance among individuals from lower income households. Individuals from higher income households showed preserved cognitive performance even with greater mean diffusivity, lower myelination, or lower neurite density. These findings provide novel mechanistic insight into associations between socioeconomic conditions, brain anatomy, and cognitive performance in middle to late adulthood.

Significance statement Pathways linking socioeconomic conditions, brain anatomy, and cognitive performance have rarely been investigated. Using multi-contrast imaging, we found that individuals from lower income households had markers of advanced brain white matter aging with lower neurite density, lower myelination, and lower iron content, alongside greater mean diffusivity. Greater mean diffusivity (reflecting myelin and neurite density) contributed to the association between household income and cognitive performance. Household income also buffered the observed white matter effects, such that greater mean diffusivity, lower index of myelin content, or lower neurite density was only associated with poorer cognitive performance among individuals from lower income households. These findings provide a detailed neurobiological understanding of socioeconomic differences in brain anatomy and associated cognitive performance.

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Language(s): eng - English
 Dates: 2024-01-182023-07-032024-01-232024-03-182024-04-24
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1523/JNEUROSCI.1231-23.2024
PMID: 38499361
PMC: PMC11044112
 Degree: -

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Funding organization : Leenaards Foundation
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Grant ID : 3200B0_105993; 3200B0_118308; 33CSCO_122661; 33CS30_139468; 33CS30_148401; 33CS30_177535; 3247730_204523; 32003B_135679; 32003B_159780; 324730_192755; CRSK-3_190185
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Funding organization : Swiss National Science Foundation (SNSF)
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Funding organization : Swiss Personalized Health Network
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Funding organization : ROGER DE SPOELBERCH and Partridge Foundations

Source 1

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Title: The Journal of Neuroscience
  Other : The Journal of Neuroscience: the Official Journal of the Society for Neuroscience
  Abbreviation : J. Neurosci.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, DC : Society of Neuroscience
Pages: - Volume / Issue: 44 (17) Sequence Number: e1231232024 Start / End Page: - Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1