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  Time is ticking faster for long genes in aging

Soheili-Nezhad, S., Ibáñez-Solé, O., Izeta, A., Hoeijmakers, J. H. J., & Stoeger, T. (2024). Time is ticking faster for long genes in aging. Trends in Genetics, 40(4), 299-312. doi:10.1016/j.tig.2024.01.009.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000F-145B-5 Version Permalink: https://hdl.handle.net/21.11116/0000-000F-28D3-6
Genre: Journal Article

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2024
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© 2024 The Author(s). Published by Elsevier Ltd. This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.
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https://creativecommons.org/licenses/by-nc-nd/4.0/

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 Creators:
Soheili-Nezhad, Sourena1, 2, Author           
Ibáñez-Solé, Olga3, 4, Author
Izeta, Ander3, 5, Author
Hoeijmakers, Jan H. J.4, 6, 7, Author
Stoeger, Thomas8, 9, Author
Affiliations:
1Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, ou_792549              
2Donders Institute for Brain, Cognition and Behaviour, External Organizations, ou_55236              
3Biogipuzkoa Health Research Institute, Donostia-San Sebastián, Spain, ou_persistent22              
4University of Cologne, Cologne, Germany, ou_persistent22              
5Tecnun-University of Navarra, Donostia-San Sebastián, Spain, ou_persistent22              
6Erasmus University Medical Center, Rotterdam, The Netherlands, ou_persistent22              
7Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands, ou_persistent22              
8Northwestern University, Chicago, IL, USA, ou_persistent22              
9Simpson Querrey Lung Institute for Translational Science, Chicago, IL, USA, ou_persistent22              

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 Abstract: Recent studies of aging organisms have identified a systematic phenomenon, characterized by a negative correlation between gene length and their expression in various cell types, species, and diseases. We term this phenomenon gene-length-dependent transcription decline (GLTD) and suggest that it may represent a bottleneck in the transcription machinery and thereby significantly contribute to aging as an etiological factor. We review potential links between GLTD and key aging processes such as DNA damage and explore their potential in identifying disease modification targets. Notably, in Alzheimer’s disease, GLTD spotlights extremely long synaptic genes at chromosomal fragile sites (CFSs) and their vulnerability to postmitotic DNA damage. We suggest that GLTD is an integral element of biological aging.

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Language(s): eng - English
 Dates: 2024-03-212024
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.tig.2024.01.009
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Title: Trends in Genetics
  Other : Trends Genet.
Source Genre: Journal
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Publ. Info: Elsevier Current Trends
Pages: - Volume / Issue: 40 (4) Sequence Number: - Start / End Page: 299 - 312 Identifier: ISSN: 0168-9525
CoNE: https://pure.mpg.de/cone/journals/resource/954925485719