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  Vasorin as an actor of bone turnover?

Andrique, C., Bonnet, A. L., Dang, J., Lesieur, J., Krautzberger, A. M., Baroukh, B., et al. (2024). Vasorin as an actor of bone turnover? Journal of Cellular Physiology. doi:10.1002/jcp.31257.

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Journal Cellular Physiology - 2024 - Andrique - Vasorin as an actor of bone turnover.pdf (Publisher version), 11MB
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Journal Cellular Physiology - 2024 - Andrique - Vasorin as an actor of bone turnover.pdf
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 Creators:
Andrique, Caroline , Author
Bonnet, Anne Laure , Author
Dang, Julien , Author
Lesieur, Julie , Author
Krautzberger, A. Michaela , Author
Baroukh, Brigitte , Author
Torrens, Coralie , Author
Sadoine, Jeremy , Author
Schmitt, Alain , Author
Rochefort, Gael Y. , Author
Bardet, Claire, Author
Six, Isabelle , Author
Houillier, Pascal , Author
Tharaux, Pierre Louis , Author
Schrewe, Heinrich1, Author                 
Gaucher, Celine , Author
Chaussain, Catherine , Author
Affiliations:
1Dept. of Developmental Genetics (Head: Bernhard G. Herrmann), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433548              

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Free keywords: bone; osteoblast; osteoclast; physiology
 Abstract: Bone diseases are increasing with aging populations and it is important to identify clues to develop innovative treatments. Vasn, which encodes vasorin (Vasn), a transmembrane protein involved in the pathophysiology of several organs, is expressed during the development in intramembranous and endochondral ossification zones. Here, we studied the impact of Vasn deletion on the osteoblast and osteoclast dialog through a cell Coculture model. In addition, we explored the bone phenotype of Vasn KO mice, either constitutive or tamoxifen-inducible, or with an osteoclast-specific deletion. First, we show that both osteoblasts and osteoclasts express Vasn. Second, we report that, in both KO mouse models but not in osteoclast-targeted KO mice, Vasn deficiency was associated with an osteopenic bone phenotype, due to an imbalance in favor of osteoclastic resorption. Finally, through the Coculture experiments, we identify a dysregulation of the Wnt/β-catenin pathway together with an increase in RANKL release by osteoblasts, which led to an enhanced osteoclast activity. This study unravels a direct role of Vasn in bone turnover, introducing a new biomarker or potential therapeutic target for bone pathologies.

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Language(s): eng - English
 Dates: 2024-03-072024-03-19
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/jcp.31257
PMID: 38504496
 Degree: -

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Title: Journal of Cellular Physiology
  Other : J. Cell. Physiol.
Source Genre: Journal
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Publ. Info: Hoboken, NJ : Wiley Subscription Services, Inc.
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0021-9541
CoNE: https://pure.mpg.de/cone/journals/resource/110992357271180