English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  PNMA2 forms immunogenic non-enveloped virus-like capsids associated with paraneoplastic neurological syndrome

Xu, J., Erlendsson, S., Singh, M., Holling, A., Regier, M., Ibiricu, I., et al. (2024). PNMA2 forms immunogenic non-enveloped virus-like capsids associated with paraneoplastic neurological syndrome. Cell, 187(4), 831-845. doi:10.1016/j.cell.2024.01.009.

Item is

Files

show Files

Locators

show

Creators

hide
 Creators:
Xu, Junjie, Author
Erlendsson, Simon, Author
Singh, Manvendra, Author
Holling, Aaron, Author
Regier, Matthew, Author
Ibiricu, Iosune1, Author           
Einstein, Jenifer, Author
Hantak, Michael P., Author
Day, Gregory S., Author
Piquet, Amanda L., Author
Smith, Tammy L., Author
Clardy, Stacey L., Author
Whiteley, Alexandra M., Author
Briggs, John A. G.1, Author                 
Shepherd, Jason D., Author
Feschotte, Cedric, Author
Affiliations:
1Briggs, John / Cell and Virus Structure, Max Planck Institute of Biochemistry, Max Planck Society, ou_3344661              

Content

hide
Free keywords: GAG PROTEIN; GENE; RNA; RETROTRANSPOSON; ENCEPHALITIS; HIPPOCAMPUS; IMMUNITY; DENSITY; SYSTEM; CORTEXBiochemistry & Molecular Biology; Cell Biology;
 Abstract: The paraneoplastic Ma antigen (PNMA) proteins are associated with cancer -induced paraneoplastic syndromes that present with an autoimmune response and neurological symptoms. Why PNMA proteins are associated with this severe autoimmune disease is unclear. PNMA genes are predominantly expressed in the central nervous system and are ectopically expressed in some tumors. We show that PNMA2, which has been co-opted from a Ty3 retrotransposon, encodes a protein that is released from cells as non -enveloped virus -like capsids. Recombinant PNMA2 capsids injected into mice induce autoantibodies that preferentially bind external "spike"PNMA2 capsid epitopes, whereas a capsid-assembly-defective PNMA2 protein is not immunogenic. PNMA2 autoantibodies in cerebrospinal fluid of patients with anti-Ma2 paraneoplastic disease show similar preferential binding to spike capsid epitopes. PNMA2 capsid-injected mice develop learning and memory deficits. These observations suggest that PNMA2 capsids act as an extracellular antigen, capable of generating an autoimmune response that results in neurological deficits.

Details

hide
Language(s): eng - English
 Dates: 2024-02-15
 Publication Status: Issued
 Pages: 35
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

hide
Title: Cell
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 187 (4) Sequence Number: - Start / End Page: 831 - 845 Identifier: ISSN: 0092-8674
CoNE: https://pure.mpg.de/cone/journals/resource/954925463183