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Abstract:
Transcription by RNA polymerase II underlies fundamental cellular processes in eukaryotic cells, representing a major regulatory hub in gene expression. Transcription is tightly coupled with co-transcriptional RNA processing to allow the synthesis of functional RNAs. A misregulation can cause human disease. The recent advent of functional multiomics approaches now provides new general insights into the molecular mechanisms that control and link transcription with RNA maturation in cells.
