Stability of a Surface-Bound Oligonucleotide Duplex Inferred from Molecular 
Dynamics: A Study of Single Nucleotide Defects Using DNA Microarrays

Naiser, Thomas; Kayser, Jona; Mai, Timo; Michel, Wolfgang; Ott, Albrecht

doi:10.1103/PhysRevLett.102.218301

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Stability of a Surface-Bound Oligonucleotide Duplex Inferred from Molecular Dynamics: A Study of Single Nucleotide Defects Using DNA Microarrays

Naiser, T., Kayser, J., Mai, T., Michel, W., & Ott, A. (2009). Stability of a Surface-Bound Oligonucleotide Duplex Inferred from Molecular Dynamics: A Study of Single Nucleotide Defects Using DNA Microarrays. PHYSICAL REVIEW LETTERS, 102(21): 218301. doi:10.1103/PhysRevLett.102.218301.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000F-2E4D-9 Version Permalink: https://hdl.handle.net/21.11116/0000-000F-2E5E-6

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https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.102.218301 (Publisher version) Open Access status unknown

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Creators:
Naiser, Thomas¹, Author
Kayser, Jona¹, Author
Mai, Timo¹, Author
Michel, Wolfgang¹, Author
Ott, Albrecht¹, Author

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1external, ou_persistent22

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Abstract: Microarray technology uses the sequence dependent hybridization
(binding) affinity of surface-bound oligonucleotide strands for the
quantification of complex nucleic acid mixtures. In spite of its huge
potential in life science and medicine, microarray oligonucleotide
hybridization remains far from being understood. Taking advantage of
microarray combinatorial possibilities we show that, although surface
bound, the hybridization affinities of single-base mismatched
oligonucleotides can be derived from first principles using parameters
from bulk.

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Language(s): eng - English

Dates: Published Online: 2009-05-26Date issued: 2009-05-26

Publication Status: Issued

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Identifiers: ISI: 000266501600057
DOI: 10.1103/PhysRevLett.102.218301

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Title: PHYSICAL REVIEW LETTERS

Source Genre: Journal

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Pages: - Volume / Issue: 102 (21) Sequence Number: 218301 Start / End Page: - Identifier: ISSN: 0031-9007