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Abstract:
The DNA sequence of hunchback, a Drosophila segmentation gene of the gap class, reveals that like Krüppel, the first gap gene analysed, it encodes a protein with finger motifs typical of a class of DNA-binding proteins. Unlike Krüppel, hunchback encodes a maternal transcript, which becomes graded along the longitudinal axis of the embyro. This, together with other features of its pattern of expression in the zygote, suggests specialization among the gap genes.