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  Identification of Arabidopsis KUMONOSU gene involved in DNA methylation and heterochromatin-associated silencing

Ikeda, Y., Becker, C., López González, L., Pouch-Pélissier, M.-N., Pogorelnik, R., Weigel, D., et al. (2014). Identification of Arabidopsis KUMONOSU gene involved in DNA methylation and heterochromatin-associated silencing. Poster presented at FEBS EMBO 2014 Conference, Paris, France.

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 Creators:
Ikeda, Y, Author
Becker, C1, Author                 
López González, L, Author
Pouch-Pélissier, M-N, Author
Pogorelnik, R, Author
Weigel, D1, Author                 
Mathieu, O, Author
Affiliations:
1Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3375790              

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 Abstract: In plants, multiple layers of epigenetic regulators are required for heterochromatin-associated silencing, including many repetitive sequences and transposable elements (Regal and Mathieu, Bio- chim Biophys Acta., 2011). However, the control mechanism of tissue specific heterochromatic silencing is still unknown. Here, we report the new Arabidopsis gene affecting hetero- chromatin-associated silencing, KUMONOSU (KUN). We iso- lated kun mutant from the screening affecting transgene silencing. In kun mutant, not only transgene, many endogenous repetitive sequence and transposable elements were activated. Moreover, the expression of specific genic regions was also affected and DNA methylation level of many target genes was slightly decreased in the mutant. Interestingly, release of silencing of the reporter transgene was observed specifically in vascular tissues of kun mutant, which may indicate possible tissue-specificity in the regulation of heterochromatin silencing.

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 Dates: 2015-08
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1111/febs.12919
 Degree: -

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Title: FEBS EMBO 2014 Conference
Place of Event: Paris, France
Start-/End Date: 2014-08-30 - 2014-09-04
Invited: Yes

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Title: The FEBS Journal
  Other : The Federation of European Biochemical Societies Journal
Source Genre: Journal
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Publ. Info: Wiley-Blackwell
Pages: - Volume / Issue: 281 (Supplement 1) Sequence Number: MON-160 Start / End Page: 304 Identifier: ISSN: 1742-464X
CoNE: https://pure.mpg.de/cone/journals/resource/954925398485