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  Subcortical control of peripheral immunity

de Araujo, I. (2024). Subcortical control of peripheral immunity. Talk presented at 88th Cold Spring Harbor Laboratory Symposium on Quantitative Biology: Brain Body Physiology. Cold Spring Harbor, NY, USA. 2024-05-29 - 2024-06-03.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000F-3921-C Version Permalink: https://hdl.handle.net/21.11116/0000-000F-7312-B
Genre: Talk

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https://meetings.cshl.edu/posters/symp24/symp2024_AbstractBook.pdf (Abstract)
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 Creators:
de Araujo, I1, Author                 
Affiliations:
1Department of Body-Brain Cybernetics, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_3515436              

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 Abstract: Altered psychological states, such as depression and chronic stress, are known to weaken body defenses against foreign pathogens. We describe a novel limbic-vagal-glandular neural circuitry that enables brain regions involved in emotional control to influence the gut microbiome. Negative psychological states impact on the activity of subcortical regions that, via downstream vagal innervation of gut tissue, alter the composition of the microbiome. A dysbiotic gut will then impact negatively on spleen and bone marrow function, abnormalities reversed by brain and vagal stimulation. The circuit here described may allow for novel neuromodulatory approaches to counter stress-induced immune vulnerability.

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 Dates: 2024
 Publication Status: Issued
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Title: 88th Cold Spring Harbor Laboratory Symposium on Quantitative Biology: Brain Body Physiology
Place of Event: Cold Spring Harbor, NY, USA
Start-/End Date: 2024-05-29 - 2024-06-03
Invited: Yes

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Title: Brain Body Physiology: Abstracts of papers presented at the LXXXVIII Cold Spring Harbor Symposium on Quantitative Biology
Source Genre: Proceedings
 Creator(s):
Leshan, R, Editor
Stewart, D, Editor
Stillman, B, Editor
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Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 43 Identifier: -

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Title: Cold Spring Harbor Symposia on Quantitative Biology
Source Genre: Series
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Publ. Info: Cold Spring Harbor, L.I., N.Y. : Biological Laboratory
Pages: - Volume / Issue: 88 Sequence Number: - Start / End Page: - Identifier: ISSN: 0091-7451
CoNE: https://pure.mpg.de/cone/journals/resource/954925463169