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  Circulating NK cells establish tissue residency upon acute infection of skin and mediate accelerated effector responses to secondary infection

Torcellan, T., Friedrich, C., Doucet-Ladevèze, R., Ossner, T., Solé, V. V., Riedmann, S., et al. (2024). Circulating NK cells establish tissue residency upon acute infection of skin and mediate accelerated effector responses to secondary infection. Immunity, 57, 124-140. doi:10.1016/j.immuni.2023.11.018.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000F-3A42-6 Version Permalink: https://hdl.handle.net/21.11116/0000-000F-3A43-5
Genre: Journal Article

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10.1016_j.immuni.2023.11.018.pdf (Publisher version), 26MB
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10.1016_j.immuni.2023.11.018.pdf
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2023
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The Author(s). Published by Elsevier Inc. All rights reserved.
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https://creativecommons.org/licenses/by-nc-nd/4.0/

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https://www.sciencedirect.com/science/article/pii/S1074761323005009?via%3Dihub (Publisher version)
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 Creators:
Torcellan, Tommaso1, Author
Friedrich, Christin1, Author
Doucet-Ladevèze, Rémi1, Author
Ossner, Thomas2, Author
Solé, Virgínia Visaconill1, Author
Riedmann, Sofie1, Author
Ugur, Milas1, Author
Imdahl, Fabian1, Author
Rosshart, Stephan P1, Author
Arnold, Sebastian J1, Author
de Agüero, Mercedes Gomez1, Author
Gagliani, Nicola1, Author
Flavell, Richard A1, Author
Backes, Simone1, Author
Kastenmüller, Wolfgang1, Author
Gasteiger, Georg1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, International Max Planck Research School for Immunobiology, Epigenetics, and Metabolism (IMPRS-IEM), ou_persistent22              

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Free keywords: Staphylococcus aureus; infection; innate immune memory; innate lymphoid cells; natural killer cells; tissue immunity; tissue-resident lymphocytes; trained immunity; vaccination; vaccinia virus.
 Abstract: Natural killer (NK) cells are present in the circulation and can also be found residing in tissues, and these populations exhibit distinct developmental requirements and are thought to differ in terms of ontogeny. Here, we investigate whether circulating conventional NK (cNK) cells can develop into long-lived tissue-resident NK (trNK) cells following acute infections. We found that viral and bacterial infections of the skin triggered the recruitment of cNK cells and their differentiation into Tcf1hiCD69hi trNK cells that share transcriptional similarity with CD56brightTCF1hi NK cells in human tissues. Skin trNK cells arose from interferon (IFN)-γ-producing effector cells and required restricted expression of the transcriptional regulator Blimp1 to optimize Tcf1-dependent trNK cell formation. Upon secondary infection, trNK cells rapidly gained effector function and mediated an accelerated NK cell response. Thus, cNK cells redistribute and permanently position at sites of previous infection via a mechanism promoting tissue residency that is distinct from Hobit-dependent developmental paths of NK cells and ILC1 seeding tissues during ontogeny.

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Language(s): eng - English
 Dates: 2024-01-09
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.immuni.2023.11.018
 Degree: -

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Title: Immunity
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 57 Sequence Number: - Start / End Page: 124 - 140 Identifier: ISSN: 1074-7613
CoNE: https://pure.mpg.de/cone/journals/resource/954925604783