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  The molecular landscape of cellular metal ion biology

Kaur Aulakh, S., Lemke, O., Szyrwiel, L., Kamrad, S., Chen, Y., Hartl, J., et al. (2024). The molecular landscape of cellular metal ion biology. bioRxiv. doi:10.1101/2024.02.29.582718.

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2024.02.29.582718v2.full.pdf (Preprint), 6MB
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2024.02.29.582718v2.full.pdf
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Kaur Aulakh, Simran , Author
Lemke, Oliver, Author
Szyrwiel, Lukasz , Author
Kamrad, Stephan , Author
Chen, Yu, Author
Hartl, Johannes , Author
Muelleder, Michael , Author
Nielsen, Jens, Author
Ralser, Markus1, 2, Author                 
Affiliations:
1Biochemistry and Systems Biology of Metabolism (Markus Ralser), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_3485956              
2Department of Biochemistry, Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany, ou_persistent22              

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 Abstract: Metal ions play crucial roles in cells, yet the broader impact of metal availability on biological networks remains underexplored. We generated genome-wide resources, systematically quantifying yeast cell growth, metallomic, proteomic, and genetic responses upon varying each of its essential metal ions (Ca, Cu, Fe, K, Mg, Mn, Mo, Na, Zn), over several orders of magnitude. We find that metal ions deeply impact cellular networks, with 57.6% of the proteome, including most signalling pathways, responding. While the biological response to each metal is distinct, our data reveals common properties of metal responsiveness, such as concentration interdependencies and metal homeostasis. We describe a compendium of metal-dependent cellular processes and reveal that several understudied genes can be functionally annotated based on their metal responses. Furthermore, we report that metalloenzymes occupy central nodes in the metabolic network and are more likely to be encoded by isozymes, resulting in system-wide responsiveness to metal availability.

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Language(s): eng - English
 Dates: 2024-03-05
 Publication Status: Published online
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 Identifiers: DOI: 10.1101/2024.02.29.582718
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Title: bioRxiv
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Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 2692-8205