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Free keywords:
anti-apoptotic Bcl-2 proteins, Apoptosis, Apoptosis Regulatory Proteins, Bax/Bak activation, bcl-2 Homologous Antagonist-Killer Protein, bcl-2-Associated X Protein, BH3-only, CRISPR-Cas Systems, Humans, Membrane Proteins, Mitochondria, Mitochondrial Membranes, Models, Biological, outer mitochondrial membrane, Permeability, Proto-Oncogene Proteins c-bcl-2
Abstract:
The minimum requirement for mitochondrial apoptosis has been controversial ever since the discovery of BCL-2 as a cell death regulator. In this issue ofGenes&Development, O'Neill and colleagues (pp. 973-988) end a long-standing debate by creating a cellular system free of BCL-2 family proteins, thereby identifying the outer mitochondrial membrane rather than BH3-only proteins as the only requirement for BAX/BAK activation and mitochondrial outer membrane permeabilization (MOMP).
