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  Flexible metallic core-shell nanostructured electrodes for neural interfacing

Rodilla, B. L., Arché‑Núñez, A., Ruiz-Gómez, S., Domínguez‑Bajo, A., Fernández‑González, C., Guillén‑Colomer, C., et al. (2024). Flexible metallic core-shell nanostructured electrodes for neural interfacing. Scientific Reports, 14: 3729, pp. 1-13. doi:10.1038/s41598-024-53719-4.

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Rodilla, Beatriz L.1, Autor
Arché‑Núñez, Ana1, Autor
Ruiz-Gómez, Sandra2, Autor           
Domínguez‑Bajo, Ana1, Autor
Fernández‑González, Claudia1, Autor
Guillén‑Colomer, Clara1, Autor
González‑Mayorga, Ankor1, Autor
Rodríguez‑Díez, Noelia1, Autor
Camarero, Julio1, Autor
Miranda, Rodolfo1, Autor
López‑Dolado, Elisa1, Autor
Ocón, Pilar1, Autor
Serrano, María C.1, Autor
Pérez, Lucas1, Autor
González, M. Teresa1, Autor
Affiliations:
1External Organizations, ou_persistent22              
2Spin3D: Three-Dimensional Magnetic Systems, Max Planck Institute for Chemical Physics of Solids, Max Planck Society, ou_3385536              

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 Zusammenfassung: Electrodes with nanostructured surface have emerged as promising low-impedance neural interfaces that can avoid the charge-injection restrictions typically associated to microelectrodes. In this work, we propose a novel approximation, based on a two-step template assisted electrodeposition technique, to obtain flexible nanostructured electrodes coated with core-shell Ni-Au vertical nanowires. These nanowires benefit from biocompatibility of the Au shell exposed to the environment and the mechanical properties of Ni that allow for nanowires longer and more homogeneous in length than their only-Au counterparts. The nanostructured electrodes show impedance values, measured by electrochemical impedance spectroscopy (EIS), at least 9 times lower than those of flat reference electrodes. This ratio is in good accordance with the increased effective surface area determined both from SEM images and cyclic voltammetry measurements, evidencing that only Au is exposed to the medium. The observed EIS profile evolution of Ni-Au electrodes over 7 days were very close to those of Au electrodes and differently from Ni ones. Finally, the morphology, viability and neuronal differentiation of rat embryonic cortical cells cultured on Ni-Au NW electrodes were found to be similar to those on control (glass) substrates and Au NW electrodes, accompanied by a lower glial cell differentiation. This positive in-vitro neural cell behavior encourages further investigation to explore the tissue responses that the implantation of these nanostructured electrodes might elicit in healthy (damaged) neural tissues in vivo, with special emphasis on eventual tissue encapsulation.

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Sprache(n): eng - English
 Datum: 2024-02-142024-02-14
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: ISI: 001163287600021
DOI: 10.1038/s41598-024-53719-4
 Art des Abschluß: -

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Titel: Scientific Reports
  Kurztitel : Sci. Rep.
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: London, UK : Nature Publishing Group
Seiten: - Band / Heft: 14 Artikelnummer: 3729 Start- / Endseite: 1 - 13 Identifikator: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322