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  A RabGAP negatively regulates plant autophagy and immune trafficking

Yuen, E. L. H., Leary, A. Y., Clavel, M., Tumtas, Y., Mohseni, A., Zhao, J., et al. (2024). A RabGAP negatively regulates plant autophagy and immune trafficking. Current Biology. doi:10.1016/j.cub.2024.04.002.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000F-3E36-0 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000F-3E38-E
Genre: Zeitschriftenartikel

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 Urheber:
Yuen, Enoch Lok Him1, Autor
Leary, Alexandre Y.1, Autor
Clavel, Marion1, Autor
Tumtas, Yasin1, Autor
Mohseni, Azadeh1, Autor
Zhao, Jierui1, Autor
Picchianti, Lorenzo1, Autor
Jamshidiha, Mostafa1, Autor
Pandey, Pooja1, Autor
Duggan, Cian1, Autor
Cota, Ernesto1, Autor
Dagdas, Yasin1, Autor
Bozkurt, Tolga O.1, Autor
Affiliations:
1external, ou_persistent22              

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Schlagwörter: RabGAP, vesicle trafficking, RXLR effectors, AlphaFold2, autophagy, plant immunity, PR1 secretion, ATG8, callose deposition, ATG8-interacting motif (AIM)
 Zusammenfassung: Summary
Plants rely on autophagy and membrane trafficking to tolerate stress, combat infections, and maintain cellular homeostasis. However, the molecular interplay between autophagy and membrane trafficking is poorly understood. Using an AI-assisted approach, we identified Rab3GAP-like (Rab3GAPL) as a key membrane trafficking node that controls plant autophagy negatively. Rab3GAPL suppresses autophagy by binding to ATG8, the core autophagy adaptor, and deactivating Rab8a, a small GTPase essential for autophagosome formation and defense-related secretion. Rab3GAPL reduces autophagic flux in three model plant species, suggesting that its negative regulatory role in autophagy is conserved in land plants. Beyond autophagy regulation, Rab3GAPL modulates focal immunity against the oomycete pathogen Phytophthora infestans by preventing defense-related secretion. Altogether, our results suggest that Rab3GAPL acts as a molecular rheostat to coordinate autophagic flux and defense-related secretion by restraining Rab8a-mediated trafficking. This unprecedented interplay between a RabGAP-Rab pair and ATG8 sheds new light on the intricate membrane transport mechanisms underlying plant autophagy and immunity.

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Sprache(n): eng - English
 Datum: 2024-04-262024-04
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1016/j.cub.2024.04.002
 Art des Abschluß: -

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Titel: Current Biology
  Kurztitel : Curr. Biol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: London, UK : Cell Press
Seiten: - Band / Heft: - Artikelnummer: - Start- / Endseite: - Identifikator: ISSN: 0960-9822
CoNE: https://pure.mpg.de/cone/journals/resource/954925579107