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  Assembling the puzzle: Oligomerization of α-pore forming proteins in membranes

Cosentino, K., Ros, U., & Garcia-Saez, A. J. (2016). Assembling the puzzle: Oligomerization of α-pore forming proteins in membranes. Biochimica et Biophysica Acta: BBA, 1858(3), 457-466. doi:10.1016/j.bbamem.2015.09.013.

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 Urheber:
Cosentino, Katia1, Autor
Ros, Uris, Autor
Garcia-Saez, Ana J.2, 3, Autor                 
Affiliations:
1External Organizations, ou_persistent22              
2Interfaculty Institute of Biochemistry, Eberhard-Karls-Universität Tübingen, Tübingen, Germany, ou_persistent22              
3Max-Planck Institute for Intelligent Systems, Stuttgart, Germany, ou_persistent22              

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Schlagwörter: Animals, Cell Membrane, Humans, Membrane, Pore forming proteins (PFPs), Pore forming toxins (PFTs), Pore structure, Porins, Protein Multimerization, Protein oligomerization, Protein Structure, Quaternary, Protein Structure, Secondary, Protein Structure, Tertiary
 Zusammenfassung: Pore forming proteins (PFPs) share the ability of creating pores that allow the passage of ions, proteins or other constituents through a wide variety of target membranes, ranging from bacteria to humans. They often cause cell death, as pore formation disrupts the membrane permeability barrier required for maintaining cell homeostasis. The organization into supramolecular complexes or oligomers that pierce the membrane is a common feature of PFPs. However, the molecular pathway of self-assembly and pore opening remains unclear. Here, we review the most recent discoveries in the mechanism of membrane oligomerization and pore formation of a subset of PFPs, the α-PFPs, whose pore-forming domains are formed by helical segments. Only now we are starting to grasp the molecular details of their function, mainly thanks to the introduction of single molecule microscopy and nanoscopy techniques. This article is part of a Special Issue entitled: Pore-forming toxins edited by Mauro Dalla Serra and Franco Gambale.

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Sprache(n): eng - English
 Datum: 2015-08-262015-06-302015-09-092015-09-122016-03
 Publikationsstatus: Erschienen
 Seiten: 10
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.bbamem.2015.09.013
BibTex Citekey: cosentino_assembling_2016
 Art des Abschluß: -

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Titel: Biochimica et Biophysica Acta : BBA
  Andere : Biochimica et Biophysica Acta (BBA) - Biomembranes
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Amsterdam : Elsevier
Seiten: - Band / Heft: 1858 (3) Artikelnummer: - Start- / Endseite: 457 - 466 Identifikator: Anderer: 1879-2642
CoNE: https://pure.mpg.de/cone/journals/resource/18792642