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  Selective autophagy of macromolecular complexes: what does it take to be taken?

Lizarrondo, J., & Wilfling, F. (2024). Selective autophagy of macromolecular complexes: what does it take to be taken? Journal of Molecular Biology, 436: 168574. doi:10.1016/j.jmb.2024.168574.

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 Creators:
Lizarrondo, Javier1, 2, Author                 
Wilfling, Florian1, Author                 
Affiliations:
1Research Group Mechanisms of Cellular Quality Control, Max Planck Institute of Biophysics, Max Planck Society, ou_3262210              
2Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt a.M., Germany, ou_persistent22              

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Free keywords: autophagy, cargo-recognition, LLPS, phase separation, protein complexes, proteostasis, Selective
 Abstract: Proteins are known to perform an astonishing array of functions thanks to their ability to cooperate and modulate each other's properties. Inside cells, proteins can assemble into large multi-subunit complexes to carry out complex cellular functions. The correct assembly and maintenance of the functional state of macromolecular protein complexes is crucial for human health. Failure to do so leads to loss of function and potential accumulation of harmful materials, which is associated with a variety of human diseases such as neurodegeneration and cancer. Autophagy engulfs cytosolic material in autophagosomes, and therefore is best suited to eliminate intact macromolecular complexes without disassembling them, which could interfere with de novo assembly. In this review, we discuss the role of autophagy in the selective degradation of macromolecular complexes. We highlight the current state of knowledge for different macromolecular complexes and their selective autophagic degradation. We emphasize the gaps in our understanding of what it takes for these large macromolecular complexes to be degraded and point to future work that may shed light on the regulation of the selective degradation of macromolecular complexes by autophagy.

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Language(s): eng - English
 Dates: 2024-01-192024-04-112024-04-162024-08-01
 Publication Status: Issued
 Pages: 18
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.jmb.2024.168574
BibTex Citekey: lizarrondo_selective_2024
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Title: Journal of Molecular Biology
  Other : JMB
  Abbreviation : J. Mol. Biol.
Source Genre: Journal
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Publ. Info: Elsevier
Pages: - Volume / Issue: 436 Sequence Number: 168574 Start / End Page: - Identifier: ISSN: 0022-2836
CoNE: https://pure.mpg.de/cone/journals/resource/0022-2836