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  Recycling of modified H2A-H2B provides short-term memory of chromatin states

Flury, V., Reverón-Gómez, N., Alcaraz, N., Stewart-Morgan, K. R., Wenger, A., Klose, R. J., et al. (2023). Recycling of modified H2A-H2B provides short-term memory of chromatin states. Cell, 186, 1050-1065. doi:10.1016/j.cell.2023.01.007.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000F-4491-0 Version Permalink: https://hdl.handle.net/21.11116/0000-000F-4492-F
Genre: Journal Article

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10.1016_j.cell.2023.01.007.pdf (Publisher version), 6MB
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10.1016_j.cell.2023.01.007.pdf
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Copyright Date:
2023
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The Author(s). Published by Elsevier Inc. All rights reserved.
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https://www.sciencedirect.com/science/article/pii/S0092867423000077?via%3Dihub (Publisher version)
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 Creators:
Flury, Valentin1, Author           
Reverón-Gómez, Nazaret2, Author
Alcaraz, Nicolas2, Author
Stewart-Morgan, Kathleen R2, Author
Wenger, Alice2, Author
Klose, Robert J2, Author
Groth, Anja2, Author
Affiliations:
1Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              
2External Organizations, ou_persistent22              

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Free keywords: DNA replication; H2A; H2A.Z; H2B; chromatin; histone PTM cross talk; histone recycling; polycomb; post-translational modifications; ubiquitination.
 Abstract: Chromatin landscapes are disrupted during DNA replication and must be restored faithfully to maintain genome regulation and cell identity. The histone H3-H4 modification landscape is restored by parental histone recycling and modification of new histones. How DNA replication impacts on histone H2A-H2B is currently unknown. Here, we measure H2A-H2B modifications and H2A.Z during DNA replication and across the cell cycle using quantitative genomics. We show that H2AK119ub1, H2BK120ub1, and H2A.Z are recycled accurately during DNA replication. Modified H2A-H2B are segregated symmetrically to daughter strands via POLA1 on the lagging strand, but independent of H3-H4 recycling. Post-replication, H2A-H2B modification and variant landscapes are quickly restored, and H2AK119ub1 guides accurate restoration of H3K27me3. This work reveals epigenetic transmission of parental H2A-H2B during DNA replication and identifies cross talk between H3-H4 and H2A-H2B modifications in epigenome propagation. We propose that rapid short-term memory of recycled H2A-H2B modifications facilitates restoration of stable H3-H4 chromatin states.

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Language(s): eng - English
 Dates: 2023-03-02
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.cell.2023.01.007
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Title: Cell
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 186 Sequence Number: - Start / End Page: 1050 - 1065 Identifier: ISSN: 0092-8674
CoNE: https://pure.mpg.de/cone/journals/resource/954925463183