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  A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1

Hai, L., Hoffmann, D. C., Wagener, R. J., Azorin, D. D., Hausmann, D., Xie, R., et al. (2024). A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1. Nature Communications, 15(1): 968, pp. 1-29. doi:10.1038/s41467-024-45067-8.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000F-4FA9-B Version Permalink: https://hdl.handle.net/21.11116/0000-000F-C801-E
Genre: Journal Article

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Creators

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 Creators:
Hai, Ling, Author
Hoffmann, Dirk C., Author
Wagener, Robin J., Author
Azorin, Daniel D., Author
Hausmann, David, Author
Xie, Ruifan, Author
Huppertz, Magnus-Carsten1, Author           
Hiblot, Julien1, Author           
Sievers, Philipp, Author
Heuer, Sophie, Author
Ito, Jakob, Author
Cebulla, Gina, Author
Kourtesakis, Alexandros, Author
Kaulen, Leon D., Author
Ratliff, Miriam, Author
Mandelbaum, Henriette, Author
Jung, Erik, Author
Jabali, Ammar, Author
Horschitz, Sandra, Author
Ernst, Kati J., Author
Reibold, Denise, AuthorWarnken, Uwe, AuthorVenkataramani, Varun, AuthorWill, Rainer, AuthorSuvà, Mario L., AuthorHerold-Mende, Christel, AuthorSahm, Felix, AuthorWinkler, Frank, AuthorSchlesner, Matthias, AuthorWick, Wolfgang, AuthorKessler, Tobias, Author more..
Affiliations:
1Chemical Biology, Max Planck Institute for Medical Research, Max Planck Society, ou_2364732              

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 Abstract: Tumor microtubes (TMs) connect glioma cells to a network with considerable relevance for tumor progression and therapy resistance. However, the determination of TM-interconnectivity in individual tumors is challenging and the impact on patient survival unresolved. Here, we establish a connectivity signature from single-cell RNA-sequenced (scRNA-Seq) xenografted primary glioblastoma (GB) cells using a dye uptake methodology, and validate it with recording of cellular calcium epochs and clinical correlations. Astrocyte-like and mesenchymal-like GB cells have the highest connectivity signature scores in scRNA-sequenced patient-derived xenografts and patient samples. In large GB cohorts, TM-network connectivity correlates with the mesenchymal subtype and dismal patient survival. CHI3L1 gene expression serves as a robust molecular marker of connectivity and functionally influences TM networks. The connectivity signature allows insights into brain tumor biology, provides a proof-of-principle that tumor cell TM-connectivity is relevant for patients' prognosis, and serves as a robust prognostic biomarker.

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Language(s): eng - English
 Dates: 2023-01-252024-01-122024-02-06
 Publication Status: Published online
 Pages: 29
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: URI: https://pubmed.ncbi.nlm.nih.gov/38320988/
URI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10847113/
DOI: 10.1038/s41467-024-45067-8
 Degree: -

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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
 Creator(s):
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 15 (1) Sequence Number: 968 Start / End Page: 1 - 29 Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723