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  Serial carcinoembryonic antigen (CEA) determinations in the management of patients with breast cancer

Staab, H.-J., Ahlemann, L., Koch, H., & Anderer, F. (1980). Serial carcinoembryonic antigen (CEA) determinations in the management of patients with breast cancer. Oncodevelopmental Biology and Medicine, 1(3), 151-160.

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 Creators:
Staab, H-J1, Author           
Ahlemann, LM, Author
Koch, HL, Author
Anderer, FA1, Author           
Affiliations:
1Anderer Group, Friedrich Miescher Laboratory, Max Planck Society, ou_3470951              

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 Abstract: Serial CEA determination have been performed in 335 patients with operable breast cancer who received radiotherapy and then were the subjects of a long-term follow-up study. Tumor extension was staged by the surgeon according to the TNM classification. Elevated pretreatment CEA levels (greater than 10 ng/ml) indicated metastatic spread even when this was not evident from the original TNM classification. Elevated CEA levels of greater than 4 ng/ml also led to a reevaluation of patients and in 20% metastatic spread was found. Therapy was adapted when patients had demonstrable distant spread. Response to treatment could be correlated with decreasing CEA levels while increasing CEA levels were generally found when disease progression was observed. During long-term CEA follow-up, 80% of recurrent cancers were signaled by increasing CEA levels. A mean lead time of 4.8 months was calculated for the initial CEA increase before clinical confirmation. Slope analysis of the posttreatment CEA time course represented a numerical parameter which was characteristic for osseous and/or liver metastases when values of greater than 0.5 ng/ml/10 days were recorded. Soft tissue, lymph node, lung and brain metastases showed generally a slope value of less than 0.5 ng/ml/10 days.

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 Dates: 1980
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: PMID: 7279702
 Degree: -

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Title: Oncodevelopmental Biology and Medicine
  Other : Oncodevelopmental Biology and Medicine: the journal of the International Society for Oncodevelopmental Biology and Medicine
  Abbreviation : Oncodev Biol Med
Source Genre: Journal
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Publ. Info: Amsterdam, the Netherlands : Elsevier
Pages: - Volume / Issue: 1 (3) Sequence Number: - Start / End Page: 151 - 160 Identifier: ISSN: 0167-1618
CoNE: https://pure.mpg.de/cone/journals/resource/0167-1618