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  Dyslexia polygenic scores show heightened prediction of verbal working memory and arithmetic

Perugini, A., Fontanillas, P., Gordon, S. D., Fisher, S. E., Martin, N. G., Bates, T. C., & Luciano, M. (2024). Dyslexia polygenic scores show heightened prediction of verbal working memory and arithmetic. Scientific Studies of Reading, 28(5), 549-563. doi:10.1080/10888438.2024.2365697.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-000F-73E3-F 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000F-C9A1-8
資料種別: 学術論文

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Perugini_etal_2024suppl_dyslexia polygenic scores show....docx (付録資料), 24KB
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https://hdl.handle.net/21.11116/0000-000F-73E6-C
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supplementary materials
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2024
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Perugini_etal_2024_dyslexia polygenic scores show....pdf (出版社版), 810KB
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ファイルのパーマリンク:
https://hdl.handle.net/21.11116/0000-000F-C9A2-7
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Perugini_etal_2024_dyslexia polygenic scores show....pdf
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-
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Hybrid
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公開
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application/pdf / [MD5]
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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent
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http://creativecommons.org/licenses/by-nc-nd/4.0/

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作成者

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 作成者:
Perugini, Ambra1, 著者
Fontanillas, Pierre2, 著者
Gordon, Scott D.3, 著者
Fisher, Simon E.4, 5, 著者           
Martin, Nicholas G.3, 著者
Bates, Timothy C.1, 著者
Luciano, Michelle1, 著者
所属:
1University of Edinburgh, Edinburgh, UK, ou_persistent22              
223andMe, Inc., Sunnyvale, CA, USA, ou_persistent22              
3QIMR Berghofer Medical Research Institute, Brisbane, Australia, ou_persistent22              
4Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, ou_792549              
5Donders Institute for Brain, Cognition and Behaviour, External Organizations, ou_55236              

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 要旨: Purpose

The aim of this study is to establish which specific cognitive abilities are phenotypically related to reading skill in adolescence and determine whether this phenotypic correlation is explained by polygenetic overlap.

Method

In an Australian population sample of twins and non-twin siblings of European ancestry (734 ≤ N ≤ 1542 [50.7% < F < 66%], mean age = 16.7, range = 11–28 years) from the Brisbane Adolescent Twin Study, mixed-effects models were used to test the association between a dyslexia polygenic score (based on genome-wide association results from a study of 51,800 dyslexics versus >1 million controls) and quantitative cognitive measures. The variance in the cognitive measure explained by the polygenic score was compared to that explained by a reading difficulties phenotype (scores that were lower than 1.5 SD below the mean reading skill) to derive the proportion of the association due to genetic influences.

Results

The strongest phenotypic correlations were between poor reading and verbal tests (R2 up to 6.2%); visuo-spatial working memory was the only measure that did not show association with poor reading. Dyslexia polygenic scores could completely explain the phenotypic covariance between poor reading and most working memory tasks and were most predictive of performance on a test of arithmetic (R2=2.9%).

Conclusion

Shared genetic pathways are thus highlighted for the commonly found association between reading and mathematics abilities, and for the verbal short-term/working memory deficits often observed in dyslexia.

資料詳細

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言語: eng - English
 日付: 2024-06-192024
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: DOI: 10.1080/10888438.2024.2365697
 学位: -

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出版物 1

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出版物名: Scientific Studies of Reading
種別: 学術雑誌
 著者・編者:
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出版社, 出版地: Mahwah, NJ : Lawrence Erlbaum Associates
ページ: - 巻号: 28 (5) 通巻号: - 開始・終了ページ: 549 - 563 識別子（ISBN, ISSN, DOIなど）: ISSN: 1088-8438
CoNE: https://pure.mpg.de/cone/journals/resource/957956064017